Rapid prolactin induction in adult male rats after treatment with diethylstilbestrol.

Autor: Maeda N; Laboratory of Meat Science and Technology, Department of Food Science and Human Wellness, Rakuno Gakuen University, Hokkaido, Japan.; Safety Research Institute for Chemical Compounds Co., Ltd, Sapporo, Japan.; Laboratory of Veterinary Biochemistry, Department of Veterinary Medicine, Rakuno Gakuen University, Hokkaido, Japan.; Japan Meat Science and Technology Institute, Shibuya-ku, Tokyo, Japan., Okumura K; Safety Research Institute for Chemical Compounds Co., Ltd, Sapporo, Japan.; Laboratory of Veterinary Biochemistry, Department of Veterinary Medicine, Rakuno Gakuen University, Hokkaido, Japan., Yamaguchi K; Laboratory of Veterinary Biochemistry, Department of Veterinary Medicine, Rakuno Gakuen University, Hokkaido, Japan.; Graduate School of Arts and Sciences, University of Tokyo, Meguro, Tokyo, Japan., Haeno S; Laboratory of Veterinary Biochemistry, Department of Veterinary Medicine, Rakuno Gakuen University, Hokkaido, Japan., Yasui Y; Laboratory of Veterinary Physiology and Nutrition, Department of Veterinary Science, Rakuno Gakuen University, Hokkaido, Japan., Kimura N; Public Nutrition, Department of Food Science and Human Wellness, Rakuno Gakuen University, Hokkaido, Japan., Ieko T; Laboratory of Veterinary Biochemistry, Department of Veterinary Medicine, Rakuno Gakuen University, Hokkaido, Japan., Miyasho T; Laboratory of Animal Biological Responses, Department of Veterinary Science, Rakuno Gakuen University, Hokkaido, Japan., Yokota H; Laboratory of Veterinary Biochemistry, Department of Veterinary Medicine, Rakuno Gakuen University, Hokkaido, Japan.
Jazyk: angličtina
Zdroj: Journal of neuroendocrinology [J Neuroendocrinol] 2019 Oct; Vol. 31 (10), pp. e12769. Date of Electronic Publication: 2019 Sep 04.
DOI: 10.1111/jne.12769
Abstrakt: Diethylstilbestrol (DES) is a synthetic oestrogen known to disrupt the endocrine system and to cause reproductive toxicity mediated via the hypothalamic-pituitary-adrenal axis; however, its molecular mechanism of action is poorly understood. In the present study, we found that, after only 1 week of exposure to DES, blood testosterone dramatically decreased and that this decrease was associated with a strong induction of prolactin (PRL). Even with the increase in PRL, the luteinising hormone and follicle-stimulating hormone mRNAs slightly decreased. Our results show that, after 48 hours of a single dose of DES, there was a six-fold increase in PRL expression. After exploring the upstream mechanisms, we determined that dopamine, which inhibits PRL secretion in male rats, did not decrease in the pituitary gland of DES-treated rats, whereas vasoactive intestinal peptide (VIP), which mediates the acute release of PRL, was elevated. Serotonin (5-HT) increased in the brain of male rats 24 hours after a single DES treatment; however, PRL, VIP or 5-HT was not induced by DES in female rats. Our results indicate that DES induces the expression of pituitary PRL in male rats by stimulating VIP in the hypothalamus and 5-HT in the central nervous system.
(© 2019 British Society for Neuroendocrinology.)
Databáze: MEDLINE
Externí odkaz:
Nepřihlášeným uživatelům se plný text nezobrazuje