The discovery BPD (D-BPD) program: study protocol of a prospective translational multicenter collaborative study to investigate determinants of chronic lung disease in very low birth weight infants.

Autor: Ofman G; Department of Pediatrics, University of Alabama at Birmingham, Birmingham, USA. gofman@peds.uab.edu.; Fundación INFANT, Buenos Aires, Argentina. gofman@peds.uab.edu., Caballero MT; Fundación INFANT, Buenos Aires, Argentina., Alvarez Paggi D; Fundación INFANT, Buenos Aires, Argentina.; National Scientific and Technical Research Council of Argentina, Buenos Aires, Argentina., Marzec J; National Institute of Environmental Health Sciences, North Carolina, USA., Nowogrodzki F; Fundación INFANT, Buenos Aires, Argentina., Cho HY; National Institute of Environmental Health Sciences, North Carolina, USA., Sorgetti M; Sanatorio de los Arcos, Buenos Aires, Argentina., Colantonio G; Sanatorio de los Arcos, Buenos Aires, Argentina., Bianchi A; Fundación INFANT, Buenos Aires, Argentina., Prudent LM; Fundación para la salud materno infantil, Buenos Aires, Argentina.; Clinica y Maternidad Suizo Argentina, Buenos Aires, Argentina., Vain N; Fundación para la salud materno infantil, Buenos Aires, Argentina.; Sanatorio de la Trinidad, Buenos Aires, Argentina., Mariani G; Hospital Italiano de Buenos Aires, Buenos Aires, Argentina., Digregorio J; Sanatorio de la Trinidad, Buenos Aires, Argentina., Turconi EL; Sanatorio de los Arcos, Buenos Aires, Argentina., Osio C; Sanatorio Otamendi y Miroli, Buenos Aires, Argentina., Galletti F; Hospital Italiano de Buenos Aires, Buenos Aires, Argentina., Quiros M; Clinica y Maternidad Suizo Argentina, Buenos Aires, Argentina., Brum A; Sanatorio de la Trinidad, Buenos Aires, Argentina., Lopez Garcia S; Sanatorio de los Arcos, Buenos Aires, Argentina., Garcia S; Sanatorio Otamendi y Miroli, Buenos Aires, Argentina., Bell D; National Institute of Environmental Health Sciences, North Carolina, USA., Jones MH; Universidade Católica do Rio Grande do Sul, Porto Alegre, Brazil., Tipple TE; Department of Pediatrics, University of Alabama at Birmingham, Birmingham, USA., Kleeberger SR; National Institute of Environmental Health Sciences, North Carolina, USA., Polack FP; Department of Pediatrics, University of Alabama at Birmingham, Birmingham, USA.
Jazyk: angličtina
Zdroj: BMC pediatrics [BMC Pediatr] 2019 Jul 06; Vol. 19 (1), pp. 227. Date of Electronic Publication: 2019 Jul 06.
DOI: 10.1186/s12887-019-1610-8
Abstrakt: Background: Premature birth is a growing and serious public health problem affecting more than one of every ten infants worldwide. Bronchopulmonary dysplasia (BPD) is the most common neonatal morbidity associated with prematurity and infants with BPD suffer from increased incidence of respiratory infections, asthma, other forms of chronic lung illness, and death (Day and Ryan, Pediatr Res 81: 210-213, 2017; Isayama et la., JAMA Pediatr 171:271-279, 2017). BPD is now understood as a longitudinal disease process influenced by the intrauterine environment during gestation and modulated by gene-environment interactions throughout the neonatal and early childhood periods. Despite of this concept, there remains a paucity of multidisciplinary team-based approaches dedicated to the comprehensive study of this complex disease.
Methods: The Discovery BPD (D-BPD) Program involves a cohort of infants < 1,250 g at birth prospectively followed until 6 years of age. The program integrates analysis of detailed clinical data by machine learning, genetic susceptibility and molecular translation studies.
Discussion: The current gap in understanding BPD as a complex multi-trait spectrum of different disease endotypes will be addressed by a bedside-to-bench and bench-to-bedside approach in the D-BPD program. The D-BPD will provide enhanced understanding of mechanisms, evolution and consequences of lung diseases in preterm infants. The D-BPD program represents a unique opportunity to combine the expertise of biologists, neonatologists, pulmonologists, geneticists and biostatisticians to examine the disease process from multiple perspectives with a singular goal of improving outcomes of premature infants.
Trial Registration: Does not apply for this study.
Databáze: MEDLINE
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