Changes in Citric Acid Cycle and Nucleoside Metabolism Are Associated with Anthracycline Cardiotoxicity in Patients with Breast Cancer.

Autor: Asnani A; CardioVascular Institute, Center for Life Sciences, Beth Israel Deaconess Medical Center and Harvard Medical School, 3 Blackfan Circle, 9th Floor, Boston, MA, 02115, USA. aasnani@bidmc.harvard.edu.; Cardiovascular Research Center and Corrigan Minehan Heart Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. aasnani@bidmc.harvard.edu., Shi X; CardioVascular Institute, Center for Life Sciences, Beth Israel Deaconess Medical Center and Harvard Medical School, 3 Blackfan Circle, 9th Floor, Boston, MA, 02115, USA.; Cardiovascular Research Center and Corrigan Minehan Heart Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Farrell L; CardioVascular Institute, Center for Life Sciences, Beth Israel Deaconess Medical Center and Harvard Medical School, 3 Blackfan Circle, 9th Floor, Boston, MA, 02115, USA.; Cardiovascular Research Center and Corrigan Minehan Heart Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Lall R; CardioVascular Institute, Center for Life Sciences, Beth Israel Deaconess Medical Center and Harvard Medical School, 3 Blackfan Circle, 9th Floor, Boston, MA, 02115, USA., Sebag IA; Sir Mortimer B. Davis-Jewish General Hospital and McGill University, Montreal, CA, USA., Plana JC; MD Anderson Cancer Center, Houston, TX, USA., Gerszten RE; CardioVascular Institute, Center for Life Sciences, Beth Israel Deaconess Medical Center and Harvard Medical School, 3 Blackfan Circle, 9th Floor, Boston, MA, 02115, USA.; Cardiovascular Research Center and Corrigan Minehan Heart Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA., Scherrer-Crosbie M; CardioVascular Institute, Center for Life Sciences, Beth Israel Deaconess Medical Center and Harvard Medical School, 3 Blackfan Circle, 9th Floor, Boston, MA, 02115, USA.; Cardiovascular Research Center and Corrigan Minehan Heart Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.; Perelman Center for Advanced Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Jazyk: angličtina
Zdroj: Journal of cardiovascular translational research [J Cardiovasc Transl Res] 2020 Jun; Vol. 13 (3), pp. 349-356. Date of Electronic Publication: 2019 Jul 05.
DOI: 10.1007/s12265-019-09897-y
Abstrakt: Anthracyclines and HER2-targeted antibodies are very effective for the treatment of breast cancer, but their use is limited by cardiotoxicity. In this nested case-control study, we assessed the role of intermediary metabolism in 38 women with breast cancer treated with anthracyclines and trastuzumab. Using targeted mass spectrometry to measure 71 metabolites in the plasma, we identified changes in citric acid and aconitic acid that differentiated patients who developed cardiotoxicity from those who did not. In patients with cardiotoxicity, the magnitude of change in citric acid at three months correlated with the change in left ventricular ejection fraction (LVEF) and absolute LVEF at nine months. Patients with cardiotoxicity also demonstrated more pronounced changes in purine and pyrimidine metabolism. Early metabolic changes may therefore provide insight into the mechanisms associated with the development of chemotherapy-associated cardiotoxicity.
Databáze: MEDLINE
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