Fueling the fire: emerging role of the hexosamine biosynthetic pathway in cancer.

Autor: Akella NM; Department of Biochemistry and Molecular Biology, Drexel University College of Medicine, Philadelphia, PA, 19102, USA., Ciraku L; Department of Biochemistry and Molecular Biology, Drexel University College of Medicine, Philadelphia, PA, 19102, USA., Reginato MJ; Department of Biochemistry and Molecular Biology, Drexel University College of Medicine, Philadelphia, PA, 19102, USA. mjr53@drexel.edu.
Jazyk: angličtina
Zdroj: BMC biology [BMC Biol] 2019 Jul 04; Vol. 17 (1), pp. 52. Date of Electronic Publication: 2019 Jul 04.
DOI: 10.1186/s12915-019-0671-3
Abstrakt: Altered metabolism and deregulated cellular energetics are now considered a hallmark of all cancers. Glucose, glutamine, fatty acids, and amino acids are the primary drivers of tumor growth and act as substrates for the hexosamine biosynthetic pathway (HBP). The HBP culminates in the production of an amino sugar uridine diphosphate N-acetylglucosamine (UDP-GlcNAc) that, along with other charged nucleotide sugars, serves as the basis for biosynthesis of glycoproteins and other glycoconjugates. These nutrient-driven post-translational modifications are highly altered in cancer and regulate protein functions in various cancer-associated processes. In this review, we discuss recent progress in understanding the mechanistic relationship between the HBP and cancer.
Databáze: MEDLINE
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