Frailty state among Indonesian elderly: prevalence, associated factors, and frailty state transition.

Autor: Setiati S; Division of Geriatric, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia. s_setiati@yahoo.com.; Clinical Epidemiology and Evidence Based Medicine Unit, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jalan Pangeran Diponegoro No. 71, Jakarta, 10430, Indonesia. s_setiati@yahoo.com., Laksmi PW; Division of Geriatric, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia., Aryana IGPS; Division of Geriatric, Departement of Internal Medicine, Faculty of Medicine, Universitas Udayana, Sanglah Teaching Hospital, Bali, Bali, Indonesia., Sunarti S; Division of Geriatric, Department of Internal Medicine, Faculty of Medicine, Universitas Brawijaya, dr. Syaiful Anwar Hospital, Malang, East Java, Indonesia., Widajanti N; Division of Geriatric, Departement of Internal Medicine, Faculty of Medicine, Universitas Airlangga, Dr. Soetomo General Hospital, Surabaya, East Java, Indonesia., Dwipa L; Division of Geriatric,Department of Internal Medicine, Faculty of Medicine, Universitas Padjajaran, Hasan Sadikin General Hospital, Bandung, West Java, Indonesia., Seto E; Division of Geriatric, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia., Istanti R; Division of Geriatric, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia., Ardian LJ; Division of Geriatric, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia., Chotimah SC; Division of Geriatric, Department of Internal Medicine, Faculty of Medicine Universitas Indonesia, Cipto Mangunkusumo Hospital, Jakarta, Indonesia.
Jazyk: angličtina
Zdroj: BMC geriatrics [BMC Geriatr] 2019 Jul 03; Vol. 19 (1), pp. 182. Date of Electronic Publication: 2019 Jul 03.
DOI: 10.1186/s12877-019-1198-8
Abstrakt: Background: Information about frailty status and its transition is important to inform clinical decisions. Predicting frailty transition is beneficial for its prevention. While Indonesia is the 4th largest geriatric population in Asia, data about frailty transition is limited. This study aimed to obtain data on prevalence of frailty, its risk factors, frailty state transition and its prognostic factors, as well as to develop prognostic score for frailty state transition.
Methods: Multicenter study on subjects aged ≥60 years old was done to obtain the prevalence of frailty status and to identify risk factors of frailty. Prospective cohort over 12 months was done to obtain data on frailty state transition. Multiple logistic regression analysis was performed to identify its prognostic factors from several clinical data, which then were utilized to develop prognostic score for frailty state worsening.
Results: Cross-sectional data from 448 subjects showed that 25.2% of the subjects were frail based on Frailty index-40 items. Risk factors of frailty were age (OR 2.72; 95% CI 1.58-4.76), functional status (OR 2.89; 95% CI 1.79-4.67), and nutritional status (OR 3.75; 95% CI 2.29-6.13). Data from the 162 subjects who completed the cohort showed 27.2% of the cohort had frailty state worsening. Prognostic factors for frailty state worsening were being 70 years or older (OR 3.9; 95% CI 1.2-12.3, p < 0.05), negative QoL, i.e., fair and poor QoL (OR 2.5; 95% CI 1.1-5.9, p < 0.05), and slow gait speed (OR 2.8; 95% CI 1.3-6.4, p < 0.05). The internal validation of the prognostic score consisted of those three variables showed good performance.
Conclusion: The prevalence of frailty in this study among Indonesian elderly in outpatient setting was 25.2%. The risk factors of frailty were age, functional status and nutritional status. The prognostic factors for frailty state worsening were being 70 years old or older, negative QoL (fair or poor quality of life), and slow gait speed. A prognostic score to predict frailty state worsening in 12 months had been developed.
Databáze: MEDLINE
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