Modulating functional connectivity between medial frontopolar cortex and amygdala by inhibitory and excitatory transcranial magnetic stimulation.

Autor:	Riedel P; Department of Psychiatry and Neuroimaging Center, Technische Universität Dresden, Dresden, Germany., Heil M; Department of Psychiatry and Neuroimaging Center, Technische Universität Dresden, Dresden, Germany., Bender S; Medical Faculty, Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, University of Cologne, Cologne, Germany., Dippel G; Department of Child and Adolescent Psychiatry and Psychotherapy, University Hospital Carl Gustav Carus, Dresden, Germany., Korb FM; Department of General Psychology, Technische Universität Dresden, Dresden, Germany., Smolka MN; Department of Psychiatry and Neuroimaging Center, Technische Universität Dresden, Dresden, Germany., Marxen M; Department of Psychiatry and Neuroimaging Center, Technische Universität Dresden, Dresden, Germany.
Jazyk:	angličtina
Zdroj:	Human brain mapping [Hum Brain Mapp] 2019 Oct 15; Vol. 40 (15), pp. 4301-4315. Date of Electronic Publication: 2019 Jul 03.
DOI:	10.1002/hbm.24703
Abstrakt:	The prefrontal-limbic network in the human brain plays a major role in social cognition, especially cognitive control of emotion. The medial frontopolar cortex (mFP; Brodmann Area 10) and the amygdala are part of this network and display correlated neuronal activity in time, as measured by functional magnetic resonance imaging (fMRI). This functional connectivity is dynamic, sensitive to training, and affected in mental disorders. However, the effects of neurostimulation on functional connectivity within this network have not yet been systematically investigated. Here, we investigate the effects of both low- and high-frequency repetitive transcranial magnetic stimulation (rTMS) to the right mFP on functional connectivity between mFP and amygdala, as measured with resting state fMRI (rsfMRI). Three groups of healthy participants received either low-frequency rTMS (1 Hz; N = 18), sham TMS (1 Hz, subthreshold; N = 18) or high-frequency rTMS (20 Hz; N = 19). rsfMRI was acquired before and after (separate days). We hypothesized a modulation of functional connectivity in opposite directions compared to sham TMS through adjustment of the stimulation frequency. Groups differed in functional connectivity between mFP and amygdala after stimulation compared to before stimulation (low-frequency: decrease, high-frequency: increase). Motion or induced changes in neuronal activity were excluded as confounders. Results show that rTMS is effective for increasing and decreasing functional coherence between prefrontal and limbic regions. This finding is relevant for social and affective neuroscience as well as novel treatment approaches in psychiatry. (© 2019 Wiley Periodicals, Inc.)
Databáze:	MEDLINE
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