Atrial fibrillation in cryptogenic stroke and transient ischaemic attack - The Nordic Atrial Fibrillation and Stroke (NOR-FIB) Study: Rationale and design.
| Autor: | Ratajczak-Tretel B; Department of Neurology, Østfold Hospital Trust, Grålum, Norway.; Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Lambert AT; Department of Neurology, Østfold Hospital Trust, Grålum, Norway.; Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Johansen H; Department of Neurology, Oslo University Hospital, Oslo, Norway., Halvorsen B; Research Institute of Internal Medicine, Oslo University Hospital, Oslo, Norway.; Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Bjerkeli V; Research Institute of Internal Medicine, Oslo University Hospital, Oslo, Norway., Russell D; Department of Neurology, Oslo University Hospital, Oslo, Norway.; Institute of Clinical Medicine, University of Oslo, Oslo, Norway., Sandset EC; Department of Neurology, Oslo University Hospital, Oslo, Norway., Ihle-Hansen H; Department of Geriatric Medicine, Oslo University Hospital, Oslo, Norway., Eriksen E; Department of Neurology, Oslo University Hospital, Oslo, Norway., Næss H; Department of Neurology, Haukeland University Hospital, Bergen, Norway., Novotny V; Department of Neurology, Haukeland University Hospital, Bergen, Norway., Khanevski AN; Department of Neurology, Haukeland University Hospital, Bergen, Norway., Truelsen TC; Department of Neurology, Rigshospitalet University Hospital, Copenhagen, Denmark., Idicula T; Department of Neurology, St. Olav University Hospital, Trondheim, Norway., Ægidius KL; Department of Neurology, Bispebjerg University Hospital, Copenhagen, Denmark., Tobro H; Department of Neurology, Telemark Hospital, Skien, Norway., Krogseth SB; Department of Neurology, Vestfold Hospital, Tønsberg, Norway., Ihle-Hansen H; Department of Internal Medicine, Vestre Viken Hospital Trust, Bærum Hospital, Bærum, Norway., Hagberg G; Department of Internal Medicine, Vestre Viken Hospital Trust, Bærum Hospital, Bærum, Norway., Kruuse C; Department of Neurology, Herlev Gentofte Hospital, Copenhagen, Denmark., Arntzen K; Department of Neurology, Nordlandssykehuset, Bodø, Norway., Bakkejord GK; Department of Neurology, Nordlandssykehuset, Bodø, Norway., Villseth M; Department of Neurology, Drammen Hospital, Vestre Viken Hospital Trust, Drammen, Norway., Nakstad I; Department of Neurology, Drammen Hospital, Vestre Viken Hospital Trust, Drammen, Norway., Eldøen G; Department of Neurology, Molde Hospital, Molde, Norway., Shafiq R; Department of Neurology, Molde Hospital, Molde, Norway., Gulsvik A; Department of Internal Medicine, Diakonhjemmet Hospital, Oslo, Norway., Kurz M; Department of Neurology, Stavanger University Hospital, Stavanger, Norway., Rezai M; Department of Neurology, Stavanger University Hospital, Stavanger, Norway., Sømark J; Department of Neurology, Innlandet Hospital Trust, Lillehammer, Norway., Tingvoll SH; Department of Neurology, Innlandet Hospital Trust, Lillehammer, Norway., Jonassen C; Center of Laboratory Medicine, Østfold Hospital Trust, Grålum, Norway.; Department of Chemistry, Biotechnology and Food Science, Norwegian University of Life Sciences, Ås, Norway., Ingebrigtsen S; Department of Neurology, University Hospital of North Norway, Tromsø, Norway., Steffensen LH; Department of Neurology, University Hospital of North Norway, Tromsø, Norway., Kremer C; Department of Neurology, Skåne University Hospital, Malmö, Sweden.; Department of Clinical Sciences, Lund University, Malmö, Sweden., Atar D; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.; Department of Cardiology B, Oslo University Hospital, Ullevål, Oslo, Norway., Aamodt AH; Department of Neurology, Oslo University Hospital, Oslo, Norway. |
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| Jazyk: | angličtina |
| Zdroj: | European stroke journal [Eur Stroke J] 2019 Jun; Vol. 4 (2), pp. 172-180. Date of Electronic Publication: 2019 Mar 19. |
| DOI: | 10.1177/2396987319837089 |
| Abstrakt: | Purpose: Paroxysmal atrial fibrillation is often suspected as a probable cause of cryptogenic stroke. Continuous long-term ECG monitoring using insertable cardiac monitors is a clinically effective technique to screen for atrial fibrillation and superior to conventional follow-up in cryptogenic stroke. However, more studies are needed to identify factors which can help selecting patients with the highest possibility of detecting atrial fibrillation with prolonged rhythm monitoring. The clinical relevance of short-term atrial fibrillation, the need for medical intervention and the evaluation as to whether intervention results in improved clinical outcomes should be assessed. Method: The Nordic Atrial Fibrillation and Stroke Study is an international, multicentre, prospective, observational trial evaluating the occurrence of occult atrial fibrillation in cryptogenic stroke and transient ischaemic attack. Patients with cryptogenic stroke or transient ischaemic attack from the Nordic countries are included and will have the Reveal LINQ® Insertable cardiac monitor system implanted for 12 months for atrial fibrillation detection. Biomarkers which can be used as predictors for atrial fibrillation and may identify patients, who could derive the most clinical benefit from the detection of atrial fibrillation by prolonged monitoring, are being studied. Conclusion: The primary endpoint is atrial fibrillation burden within 12 months of continuous rhythm monitoring. Secondary endpoints are atrial fibrillation burden within six months, levels of biomarkers predicting atrial fibrillation, CHA |
| Databáze: | MEDLINE |
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