| Autor: |
Majchrzak M; Department of Thoracic Surgery, Medical University in Wroclaw, Wroclaw, Poland., Brzecka A; Department of Pulmonology and Lung Cancer, Medical University in Wroclaw, Wroclaw, Poland., Daroszewski C; Department of Pulmonology and Lung Cancer, Medical University in Wroclaw, Wroclaw, Poland., Błasiak P; Department of Thoracic Surgery, Medical University in Wroclaw, Wroclaw, Poland., Rzechonek A; Department of Thoracic Surgery, Medical University in Wroclaw, Wroclaw, Poland., Tarasov VV; Department of Pharmacology and Pharmacy, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia., Chubarev VN; Department of Pharmacology and Pharmacy, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia., Kurinnaya AS; Department of Pharmacology and Pharmacy, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia., Melnikova TI; Department of Pharmacology and Pharmacy, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia., Makhmutova A; Institute of Physiologically Active Compounds, Russian Academy of Sciences, Chernogolovka, Russia., Klochkov SG; Institute of Physiologically Active Compounds, Russian Academy of Sciences, Chernogolovka, Russia., Somasundaram SG; Department of Biological Sciences, Salem University, Salem, WV, United States., Kirkland CE; Department of Biological Sciences, Salem University, Salem, WV, United States., Aliev G; Department of Pharmacology and Pharmacy, I.M. Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.; Institute of Physiologically Active Compounds, Russian Academy of Sciences, Chernogolovka, Russia.; GALLY International Biomedical Research Institute, San Antonio, TX, United States. |
| Abstrakt: |
Background: Obesity and cancer are recognized worldwide health threats. While there is no reported causal relationship, the increasing frequency of both conditions results in a higher incidence of obese patients who are being treated for cancer. Physiological data indicate that there is a relationship between obesity and susceptibility to pain; however, currently, there are no specific pharmacological interventions. Objective: To evaluate the self-reported intensity of postoperative pain in obese and nonobese lung cancer who receive either thoracotomy or video-assisted thoracic surgery (VATS) surgical therapy. Material and Methods: In 50 obese [mean body mass index (BMI) of 34.1 ± 3.2 kg/m 2 ] and 62 nonobese (mean BMI of 24.9 ± 3 kg/m 2 ) lung cancer patients, the intensity of pain was estimated every 4 h using a visual analog scale (VAS, 0 indicating no pain and 10 indicating "worst imaginable pain") beginning shortly after surgery (Day O) and continuing until the day of discharge (Day D). Results: The self-reported pain was more severe in obese than in nonobese patients, both at the time of the operation [Day O (4.5 ± 1.2 vs 3.4 ± 1.1; p < 0.0001)] and at the day of discharge [Day D (3.9 ± 1.4 vs 2.6 ± 0.9, p < 0.0001)]. This finding was consistent both in the patients after thoracotomy and after video-assisted thoracic surgery (VATS, p < 0.0001). The patients with severe pain shortly after surgery (VAS score >4) had significantly higher BMI (31.8 ± 5.6 kg/m 2 vs 28.8 ± 5.2 kg/m 2 , p < 0.01) and were hospitalized longer than the remaining patients (13.0 ± 13.6 days vs 9.5 ± 3.6 days, p < 0.05). Conclusion: The reported perception of pain in obese lung cancer patients is greater than in nonobese patients undergoing the same thoracic surgery. In obese patients, severe pain persisted longer. Pain management is an important consideration in the postoperative care of lung cancer patients, even more so with obese patients. |
