| Autor: |
Klyueva NN; Institute of Experimental Medicine, Saint-Petersburg, Russia., Okunevich IV; Institute of Experimental Medicine, Saint-Petersburg, Russia., Parfenova NS; Institute of Experimental Medicine, Saint-Petersburg, Russia., Belova EV; Institute of Experimental Medicine, Saint-Petersburg, Russia., Ageeva EV; Institute of Experimental Medicine, Saint-Petersburg, Russia. |
| Jazyk: |
ruština |
| Zdroj: |
Biomeditsinskaia khimiia [Biomed Khim] 2019 Apr; Vol. 65 (3), pp. 227-230. |
| DOI: |
10.18097/PBMC20196503227 |
| Abstrakt: |
The experimental study in vivo was aimed at evaluation of hypolipidemic action of the original natural microbial enzyme preparation of cholesterol oxidase (CHO). In preliminary chronic experiments in rats, rabbits, dogs, low toxicity, good tolerability, and anti-atherosclerotic activity of the CHO preparation were established. To assess the effect of CHO under conditions of moderate, nutritional, atherogenic dyslipoproteinemia, experiments were carried out in rats, guinea pigs, and rabbits. It was shown that administration of CHO had the pronounced lipid-lowering effect in models of atherogenic dyslipoproteinemia induced in these animals. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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