| Autor: |
Volcão LM; Insituto de Ciências Biológicas, Universidade Federal do Rio Grande , Rio Grande, Brasil., Halicki PB; Núcleo de Pesquisa em Desenvolvimento de Novos Fármacos, Faculdade de Medicina, Universidade Federal do Rio Grande , Rio Grande, Brasil., Bilibio D; Núcleo de Experimentação e Estudos Analíticos, Instituto Federal de Educação, Ciência e Tecnologia do Rio Grande do Sul , Sertã, Brasil., Ramos DF; Núcleo de Pesquisa em Desenvolvimento de Novos Fármacos, Faculdade de Medicina, Universidade Federal do Rio Grande , Rio Grande, Brasil., Bernardi E; Departamento de Microbiologia e Parasitologia, Universidade Federal de Pelotas , Pelotas, Brasil., Da Silva Júnior FMR; Insituto de Ciências Biológicas, Universidade Federal do Rio Grande , Rio Grande, Brasil. |
| Abstrakt: |
This study aims to perform a bioactive analysis of five mushrooms collected in south of Brazil. The total phenol content of the extracts was equivalent to the antioxidant activity by ACAP assay. All extracts were able to inhibit the growth of Acinetobacter baumanni, and Auricularia auricula and Lactarius deliciosus extract showed the best antibacterial activity. In addition, no extract showed cytotoxic activity against VERO cells at the highest concentration evaluated (2500 µg/mL). Our results showed better antioxidant activity through the inhibition of the oxidation via peroxyl radical. It can be observed that all extracts were active against A. baumanni, and even moderately, all extracts could be inhibited of at least one of the bacteria used in the study. Added for these, the aqueous extracts showed no toxicity in VERO cells, highlighting the importance of research about the active compounds of mushrooms of the region. |
