| Autor: |
Rabinowitz JA; Bloomberg School of Public Health, Department of Mental Health, Johns Hopkins University, Baltimore, MD, USA., Musci RJ; Bloomberg School of Public Health, Department of Mental Health, Johns Hopkins University, Baltimore, MD, USA., Reboussin B; School of Medicine, Wake Forest University, Winston-Salem, NC, USA., Milam AJ; Bloomberg School of Public Health, Department of Mental Health, Johns Hopkins University, Baltimore, MD, USA., Benke KS; Bloomberg School of Public Health, Department of Mental Health, Johns Hopkins University, Baltimore, MD, USA., Uhl GR; New Mexico VA Health Care System, Albuquerque, New Mexico, USA., Sisto DY; Bloomberg School of Public Health, Department of Mental Health, Johns Hopkins University, Baltimore, MD, USA., Ialongo NS; Bloomberg School of Public Health, Department of Mental Health, Johns Hopkins University, Baltimore, MD, USA., Maher BS; Bloomberg School of Public Health, Department of Mental Health, Johns Hopkins University, Baltimore, MD, USA. |
| Abstrakt: |
The study examined (a) whether alcohol use subgroups could be identified among African Americans assessed from adolescence through early adulthood, and (b) whether subgroup membership was associated with the interaction between internalizing symptoms and antisocial behavior polygenic risk scores (PRSs) and environmental characteristics (i.e., parental monitoring, community disadvantage). Participants (N = 436) were initially recruited for an elementary school-based prevention trial in a Mid-Atlantic city. Youths reported on the frequency of their past year alcohol use from ages 14-26. DNA was obtained from participants at age 21. Internalizing symptoms and antisocial behavior PRSs were created based on a genome-wide association study (GWAS) conducted by Benke et al. (2014) and Tielbeek et al. (2017), respectively. Parental monitoring and community disadvantage were assessed at age 12. Four classes of past year alcohol use were identified: (a) early-onset, increasing; (b) late-onset, moderate use; (c) low steady; and (d) early-onset, decreasing. In high community disadvantaged settings, participants with a higher internalizing symptoms PRS were more likely to be in the early-onset, decreasing class than the low steady class. When exposed to elevated community disadvantage, participants with a higher antisocial behavior PRS were more likely to be in the early-onset, increasing class than the early-onset, decreasing and late-onset, moderate use classes. |
