Clinical and equipment-related factors associated with the adequate peripheral blood stem cell collection in autologous transplant at a tertiary cancer center in Kerala - A retrospective cohort study.

Autor: Murugesan M; Dept. of Transfusion Medicine, Malabar Cancer Centre, Thalassery, Kerala, India. Electronic address: drmohandossm@gmail.com., Shringarpure K; Dept. of PSM, Medical College Baroda, Gujarat, India., Karthickeyan DSA; Academy for Public Health, Calicut, Kerala, India., Nair CK; Dept. of Clinical Hematology, Malabar Cancer Centre, Thalassery, Kerala, India., Nayanar SK; Dept. of Oncopathology, Malabar Cancer Centre, Thalassery, Kerala, India., Venugopal V; Dept. of Community Medicine, Sri Manakula Vinayagar Medical College, Puducherry, India., Selvaraj K; Dept. of Community Medicine, All India Institute of Medical Sciences, Nagpur, India., Rathi P; Dept. of Community Medicine, Kasturba Medical College, Mangalore, India., Mehta KG; Community Medicine Department, GMERS Medical college Gotri, Vadodara, India., Deenathayalan V; Academy for Public Health, Calicut, Kerala, India., Gayathiri KC; Dept. of Transfusion Medicine, Malabar Cancer Centre, Thalassery, Kerala, India.
Jazyk: angličtina
Zdroj: Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis [Transfus Apher Sci] 2019 Aug; Vol. 58 (4), pp. 457-463. Date of Electronic Publication: 2019 Jun 21.
DOI: 10.1016/j.transci.2019.05.007
Abstrakt: Background: PBSC collection using apheresis is the preferred source of hematopoietic stem cells transplantation. However, apheresis procedures fail to harvest adequate CD34 yield in 5 to 40% of patients during the first collection. Therefore, this study aimed to study both the clinical- and equipmentrelated factors influencing CD34 yield among the autologous patients and to compare the collection efficiency of two apheresis equipments(Haemonetics MCS+ and Terumo Spectra Optia).
Methods: Retrospective analysis of 69 patients underwent PBSC collection from 2015 to 2018. Frequency, clinical- and equipment-related factors responsible for adequate CD34+ cells (≥2 x106 cells/kg) yield during the first collection was studied. Factors such as collection efficiency, percentage platelet loss and percentage hemoglobin loss were considered to compare the two apheresis system.
Results: Two-third (72%) patients of the study population had adequate CD34 stem cells yield during the first collection. Factors such as exposure to lenalidomide-based pretreatment regimen, peripheral blood WBC count and CD34 count are associated with the adequate CD34 yield. Optia had a slightly better collection efficiency than MCS+ (50 and 44; p=0.37). Optia had lower product volume (237 vs 298 ml) and lesser procedure duration (277 vs 360 min), whereas the median Hb loss (3.0% and 2.3%) and mean platelet loss (49% and 34%) were higher with MCS.
Conclusion: This study infers that the collection efficiency of both the equipments in collecting CD34 stem cells was similar. However, during PBSC collection, procedures using Optia can be preferred to MCS+ on the patients with risk of anemia and thrombocytopenia.
(Copyright © 2019. Published by Elsevier Ltd.)
Databáze: MEDLINE
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