Possible Existence of the Hypothalamic-Pituitary-Hippocampal (HPH) Axis: A Reciprocal Relationship Between Hippocampal Specific Neuroestradiol Synthesis and Neuroblastosis in Ageing Brains with Special Reference to Menopause and Neurocognitive Disorders.

Autor: Kandasamy M; Laboratory of Stem Cells and Neuroregeneration, Department of Animal Science, School of Life Sciences, Bharathidasan University, Tiruchirappalli, Tamil Nadu, 620024, India. pkmahesh5@gmail.com.; Department of Animal Science, School of Life Sciences, Bharathidasan University, Tiruchirappalli, Tamil Nadu, 620024, India. pkmahesh5@gmail.com.; School of Life Sciences, Bharathidasan University, Tiruchirappalli, Tamil Nadu, 620024, India. pkmahesh5@gmail.com.; Faculty Recharge Programme, University Grants Commission(UGC-FRP), New Delhi, India. pkmahesh5@gmail.com., Radhakrishnan RK; Laboratory of Stem Cells and Neuroregeneration, Department of Animal Science, School of Life Sciences, Bharathidasan University, Tiruchirappalli, Tamil Nadu, 620024, India.; Department of Animal Science, School of Life Sciences, Bharathidasan University, Tiruchirappalli, Tamil Nadu, 620024, India., Poornimai Abirami GP; School of Life Sciences, Bharathidasan University, Tiruchirappalli, Tamil Nadu, 620024, India., Roshan SA; Molecular Gerontology Laboratory, Department of Biochemistry, School of Life Sciences, Bharathidasan University, Tiruchirappalli, Tamil Nadu, 620024, India.; Department of Biochemistry, Bharathidasan University, Tiruchirappalli, 620024, India., Yesudhas A; Laboratory of Stem Cells and Neuroregeneration, Department of Animal Science, School of Life Sciences, Bharathidasan University, Tiruchirappalli, Tamil Nadu, 620024, India.; Department of Animal Science, School of Life Sciences, Bharathidasan University, Tiruchirappalli, Tamil Nadu, 620024, India., Balamuthu K; Department of Animal Science, School of Life Sciences, Bharathidasan University, Tiruchirappalli, Tamil Nadu, 620024, India.; School of Life Sciences, Bharathidasan University, Tiruchirappalli, Tamil Nadu, 620024, India., Prahalathan C; School of Life Sciences, Bharathidasan University, Tiruchirappalli, Tamil Nadu, 620024, India.; Department of Biochemistry, Bharathidasan University, Tiruchirappalli, 620024, India., Shanmugaapriya S; Department of Bio-Medical Science, Bharathidasan University, Tiruchirappalli, Tamil Nadu, India., Moorthy A; Department of Integrative Biology, School of Bioscience and Technology, Vellore Institute of Technology, Vellore, Tamil Nadu, 632014, India., Essa MM; Department of Food Science and Nutrition, College of Agricultural and Marine Sciences, Sultan Qaboos University, Muscat, Oman.; Ageing and Dementia Research Group, Sultan Qaboos University, Muscat, Oman., Anusuyadevi M; School of Life Sciences, Bharathidasan University, Tiruchirappalli, Tamil Nadu, 620024, India.; Molecular Gerontology Laboratory, Department of Biochemistry, School of Life Sciences, Bharathidasan University, Tiruchirappalli, Tamil Nadu, 620024, India.; Department of Biochemistry, Bharathidasan University, Tiruchirappalli, 620024, India.
Jazyk: angličtina
Zdroj: Neurochemical research [Neurochem Res] 2019 Aug; Vol. 44 (8), pp. 1781-1795. Date of Electronic Publication: 2019 Jun 28.
DOI: 10.1007/s11064-019-02833-1
Abstrakt: The hippocampus-derived neuroestradiol plays a major role in neuroplasticity, independent of circulating estradiol that originates from gonads. The response of hypothalamus-pituitary regions towards the synthesis of neuroestradiol in the hippocampus is an emerging scientific concept in cognitive neuroscience. Hippocampal plasticity has been proposed to be regulated via neuroblasts, a major cellular determinant of functional neurogenesis in the adult brain. Defects in differentiation, integration and survival of neuroblasts in the hippocampus appear to be an underlying cause of neurocognitive disorders. Gonadotropin receptors and steroidogenic enzymes have been found to be expressed in neuroblasts in the hippocampus of the brain. However, the reciprocal relationship between hippocampal-specific neuroestradiol synthesis along neuroblastosis and response of pituitary based feedback regulation towards regulation of estradiol level in the hippocampus have not completely been ascertained. Therefore, this conceptual article revisits (1) the cellular basis of neuroestradiol synthesis (2) a potential relationship between neuroestradiol synthesis and neuroblastosis in the hippocampus (3) the possible involvement of aberrant neuroestradiol production with mitochondrial dysfunctions and dyslipidemia in menopause and adult-onset neurodegenerative disorders and (4) provides a hypothesis for the possible existence of the hypothalamic-pituitary-hippocampal (HPH) axis in the adult brain. Eventually, understanding the regulation of hippocampal neurogenesis by abnormal levels of neuroestradiol concentration in association with the feedback regulation of HPH axis might provide additional cues to establish a neuroregenerative therapeutic management for mood swings, depression and cognitive decline in menopause and neurocognitive disorders.
Databáze: MEDLINE
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