"886-84-like" tick-borne encephalitis virus strains: Intraspecific status elucidated by comparative genomics.

Autor: Adelshin RV; Irkutsk Anti-Plague Research Institute of Siberia and Far East, Trilisser 78, 664047, Irkutsk, Russia; Irkutsk State University, Irkutsk, Russia. Electronic address: adelshin@gmail.com., Sidorova EA; Irkutsk Anti-Plague Research Institute of Siberia and Far East, Trilisser 78, 664047, Irkutsk, Russia., Bondaryuk AN; Irkutsk Anti-Plague Research Institute of Siberia and Far East, Trilisser 78, 664047, Irkutsk, Russia., Trukhina AG; Irkutsk Anti-Plague Research Institute of Siberia and Far East, Trilisser 78, 664047, Irkutsk, Russia., Sherbakov DY; Irkutsk State University, Irkutsk, Russia; Limnological Institute, Siberian Branch of the Russian Academy of Sciences, Irkutsk, Russia., White Iii RA; RAW Molecular Systems, Spokane, WA, United States; Crop and Soil Sciences, Washington State University, Pullman, WA, United States; Plant Pathology, Washington State University, Pullman, WA, United States; Australian Centre for Astrobiology, University of New South Wales, Sydney, NSW, Australia., Andaev EI; Irkutsk Anti-Plague Research Institute of Siberia and Far East, Trilisser 78, 664047, Irkutsk, Russia., Balakhonov SV; Irkutsk Anti-Plague Research Institute of Siberia and Far East, Trilisser 78, 664047, Irkutsk, Russia.
Jazyk: angličtina
Zdroj: Ticks and tick-borne diseases [Ticks Tick Borne Dis] 2019 Aug; Vol. 10 (5), pp. 1168-1172. Date of Electronic Publication: 2019 Jun 15.
DOI: 10.1016/j.ttbdis.2019.06.006
Abstrakt: Tick-borne encephalitis virus (TBEV) can cause severe meningitis, encephalitis, and meningoencephalitis. TBEV represents a pathogen of high zoonotic potential and an emerging global threat. There are three known subtypes of TBEV: Far-Eastern, Siberian and European. Since 2001 there have been suggestions that two new subtypes may be distinguished: "178-79" and "886-84". These assumptions are based on the results of the envelope gene fragment sequencing (Zlobin et al., 2001; Kovalev and Mukhacheva, 2017) and genotype-specific probes molecular hybridization (Demina et al., 2010). There is only one full-genome sequence of "178-79" strain and two identical ones of "886-84" strain can be found in GenBank. For clarification of the intraspecific position of the "886-84-like" strains group we completely sequenced six previously unknown "886-84-like" strains isolated in Eastern Siberia. As a result of applying different bioinformatics approaches, we can confirm that "886-84-like" strains group is a distinct subtype of TBEV.
(Copyright © 2019 Elsevier GmbH. All rights reserved.)
Databáze: MEDLINE
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