| Autor: |
Von Behren J; Cancer Prevention Institute of California, Fremont, CA 94538, USA. Julie.Vonbehren@ucsf.edu.; Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA 94158, USA. Julie.Vonbehren@ucsf.edu., Liu R; Cancer Prevention Institute of California, Fremont, CA 94538, USA., Sellen J; Sierra Streams Institute, Nevada City, CA 95959, USA., Duffy CN; Cancer Prevention Institute of California, Fremont, CA 94538, USA.; Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA 94158, USA., Gajek R; Environmental Health Laboratory, California Department of Public Health, Richmond, CA 94804, USA., Choe KY; Environmental Health Laboratory, California Department of Public Health, Richmond, CA 94804, USA., DeGuzman J; Environmental Health Laboratory, California Department of Public Health, Richmond, CA 94804, USA., Janes MK; Sierra Streams Institute, Nevada City, CA 95959, USA., Hild J; Sierra Streams Institute, Nevada City, CA 95959, USA., Reynolds P; Cancer Prevention Institute of California, Fremont, CA 94538, USA.; Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA 94158, USA. |
| Abstrakt: |
Gold mining activities occurred throughout the foothills of the Sierra Nevada Mountains in California, leaving behind persistent toxic contaminants in the soil, dust, and water that include arsenic and cadmium. Despite a high level of concern among local residents about potential exposure and high breast cancer rates, no biomonitoring data has been collected to evaluate the levels of heavy metals. We conducted a study to characterize the urinary levels of heavy metals among women in this region by working with the community in Nevada County. Sixty women provided urine samples and completed a questionnaire. We examined levels of arsenic, cadmium, and other metals in relation to the length of residency in the area, age, dietary factors, recreational activities, and smoking. We compared urinary metal levels in participants to levels in the United States National Health and Nutrition Examination Survey (NHANES). Overall, study participants had higher urinary levels of arsenic than women in the national sample. Cadmium levels were similar to the national average, although they were elevated in women ≥35 years who had lived in the region for 10 years or more. Arsenic levels were higher among women who smoked, ate fish, ate home-grown produce, and who reported frequent hiking or trail running, although these differences were not statistically significant. This study established a successful community-research partnership, which facilitated community dialogue about possible human health consequences of living in a mining-impacted area. |
