Comparison of various types of inert gas components on efficacy of an alveolar recruitment maneuver in dorsally recumbent anesthetized horses.

Autor: Varner KM, Hopster K, Driessen B
Jazyk: angličtina
Zdroj: American journal of veterinary research [Am J Vet Res] 2019 Jul; Vol. 80 (7), pp. 631-636.
DOI: 10.2460/ajvr.80.7.631
Abstrakt: Objective: To assess effects of nitrogen and helium on efficacy of an alveolar recruitment maneuver (ARM) for improving pulmonary mechanics and oxygen exchange in anesthetized horses.
Animals: 6 healthy adult horses.
Procedures: Horses were anesthetized twice in a randomized crossover study. Isoflurane-anesthetized horses in dorsal recumbency were ventilated with 30% oxygen and 70% nitrogen (treatment N) or heliox (30% oxygen and 70% helium; treatment H) as carrier gas. After 60 minutes, an ARM was performed. Optimal positive end-expiratory pressure was identified and maintained for 120 minutes. Throughout the experiment, arterial blood pressures, heart rate, peak inspiratory pressure, dynamic compliance (C dyn ), and Pao 2 were measured. Variables were compared with baseline values and between treatments by use of an ANOVA.
Results: The ARM resulted in significant increases in Pao 2 and C dyn and decreases in the alveolar-arterial gradient in the partial pressure of oxygen in all horses. After the ARM and during the subsequent 120-minute phase, mean values were significantly lower for treatment N than treatment H for Pao 2 and C dyn . Optimal positive end-expiratory pressure was consistently 15 cm H 2 O for treatment N, but it was 10 cm H 2 O (4 horses) and 15 cm H 2 O (2 horses) for treatment H.
Conclusions and Clinical Relevance: An ARM in anesthetized horses might be more efficacious in improving Pao 2 and C dyn when animals breathe helium instead of nitrogen as the inert gas.
Databáze: MEDLINE
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