Electromagnetic Fields, Genomic Instability and Cancer: A Systems Biological View.

Autor:	Naarala J; Department of Environmental and Biological Sciences, University of Eastern Finland, Kuopio, FI-70210, Finland. jonne.naarala@uef.fi., Kolehmainen M; Department of Environmental and Biological Sciences, University of Eastern Finland, Kuopio, FI-70210, Finland. mikko.kolehmainen@uef.fi., Juutilainen J
Jazyk:	angličtina
Zdroj:	Genes [Genes (Basel)] 2019 Jun 25; Vol. 10 (6). Date of Electronic Publication: 2019 Jun 25.
DOI:	10.3390/genes10060479
Abstrakt:	This review discusses the use of systems biology in understanding the biological effectsof electromagnetic fields, with particular focus on induction of genomic instability and cancer. Weintroduce basic concepts of the dynamical systems theory such as the state space and attractors andthe use of these concepts in understanding the behavior of complex biological systems. We thendiscuss genomic instability in the framework of the dynamical systems theory, and describe thehypothesis that environmentally induced genomic instability corresponds to abnormal attractorstates; large enough environmental perturbations can force the biological system to leave normalevolutionarily optimized attractors (corresponding to normal cell phenotypes) and migrate to lessstable variant attractors. We discuss experimental approaches that can be coupled with theoreticalsystems biology such as testable predictions, derived from the theory and experimental methods,that can be used for measuring the state of the complex biological system. We also reviewpotentially informative studies and make recommendations for further studies. Competing Interests: The authors declare no conflicts of interest. The funders had no role in the design of the study; in the collection, analyses, or interpretation of data; in the writing of the manuscript; or in the decision to publish the results.
Databáze:	MEDLINE
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