Autor: |
Zemskov VM; A.V. Vishnevsky National Medical Research Center of Surgery, Moscow 117997, Russia. arturrego@yandex.ru.; Department of Research and Development at Facecontrol, Inc., Miami, FL 33131, USA. arturrego@yandex.ru., Pronko KN; Department of Research and Development at Facecontrol, Inc., Miami, FL 33131, USA. k.pronko@facecontrol.biz., Ionkin DA; A.V. Vishnevsky National Medical Research Center of Surgery, Moscow 117997, Russia. ionkin@ixv.ru., Chzhao AV; A.V. Vishnevsky National Medical Research Center of Surgery, Moscow 117997, Russia. chzhao@ixv.ru., Kozlova MN; A.V. Vishnevsky National Medical Research Center of Surgery, Moscow 117997, Russia. kozlova@ixv.ru., Barsukov AA; A.V. Vishnevsky National Medical Research Center of Surgery, Moscow 117997, Russia. barsukov@ixv.ru., Shishkina NS; A.V. Vishnevsky National Medical Research Center of Surgery, Moscow 117997, Russia. nadya-vesy@mail.ru., Demidova VS; A.V. Vishnevsky National Medical Research Center of Surgery, Moscow 117997, Russia. demidova@ixv.ru., Zemskov AM; Department of Microbiology of Burdenko, Voronezh State Medical University, Voronezh 394000, Russia. zemskov@vsmaburdenko.ru., Revishvili AS; A.V. Vishnevsky National Medical Research Center of Surgery, Moscow 117997, Russia. amirevi@mail.ru. |
Abstrakt: |
Cryosurgery used on patients with unresectable pancreatic cancer improved their quality of life, but mainly because of the pain relief. In postoperative patients, multifaceted changes in immunity were found, and the state of the immune system prior to surgery often was a decisive factor to indicate whether further disorders in the postoperative period would develop, or by contrast, it would boost its recovery. Some patients receiving cryosurgery showed immune system imbalance and activation, and of antitumor immunity in particular. It has been suggested that the advisability of immunotropic therapy for specific treatment algorithms should be predicted or the therapy should be suspended at some pathologic stage, and this has been immunologically confirmed. Cryosurgery should be considered as a reasonable alternative to the existing types of surgery for pancreatic cancer or as an essential component of multimodal therapy, consisting of topical cryosurgery, chemotherapy, and immunotropic therapy, to boost antitumor immunity and to discontinue cytoreductive therapy due to its toxic effects. |