| Autor: |
da Silva Júnior WF; Pharmacy Department, Universidade Federal do Rio Grande do Norte, Natal 59012-570, RN, Brazil. walterjuniornt@hotmail.com., Bezerra de Menezes DL; Pharmacy Department, Universidade Federal do Rio Grande do Norte, Natal 59012-570, RN, Brazil. daniellelbmenezes@gmail.com., de Oliveira LC; Pharmacy Department, Universidade Federal do Rio Grande do Norte, Natal 59012-570, RN, Brazil. farmaceuticalu@hotmail.com., Koester LS; Production and Drug Control Department, Universidade Federal do Rio Grande do Sul, Porto Alegre 90610-000, RS, Brazil. leticia.koester@ufrgs.br., Oliveira de Almeida PD; Laboratory of Biological Activity, Faculty of Pharmaceutical Sciences, Universidade Federal do Amazonas, Manaus 69077-000, AM, Brazil. patt_danielle@hotmail.com., Lima ES; Laboratory of Biological Activity, Faculty of Pharmaceutical Sciences, Universidade Federal do Amazonas, Manaus 69077-000, AM, Brazil. eslima75@gmail.com., de Azevedo EP; Graduate Program of Biotechnology, Laureate International Universities (UnP), Natal 59056-000, RN, Brazil. azevedoep@hotmail.com., da Veiga Júnior VF; Chemical Engineering Department, Military Institute of Engineering, Rio de Janeiro 22290-270, RJ, Brazil. valdir.veiga@gmail.com., Neves de Lima ÁA; Pharmacy Department, Universidade Federal do Rio Grande do Norte, Natal 59012-570, RN, Brazil. adleyantonini@yahoo.com.br. |
| Abstrakt: |
α, β amyrin (ABAM) is a natural mixture of pentacyclic triterpenes that has a wide range of biological activities. ABAM is isolated from the species of the Burseraceae family, in which the species Protium is commonly found in the Amazon region of Brazil. The aim of this work was to develop inclusion complexes (ICs) of ABAM and β-cyclodextrin (βCD) and hydroxypropyl-β-cyclodextrin (HPβCD) by physical mixing (PM) and kneading (KN) methods. Interactions between ABAM and the CD's as well as the formation of ICs were confirmed by physicochemical characterization in the solid state by Fourier transform infrared (FTIR), scanning electron microscopy (SEM), X-ray diffraction (XRD), thermogravimetry (TG) and differential scanning calorimetry (DSC). Physicochemical characterization indicated the formation of ICs with both βCD and HPβCD. Such ICs were able to induce changes in the physicochemical properties of ABAM. In addition, the formation of ICs with cyclodextrins showed to be an effective and promising alternative to enhance the anti-inflammatory activity and safety of ABAM. |
