| Autor: |
Harbeck RJ; Department of Medicine, National Jewish Center for Immunology and Respiratory Medicine, Denver, Colorado 80206., Gegen NW, Struhar D, Mason R |
| Jazyk: |
angličtina |
| Zdroj: |
Cellular immunology [Cell Immunol] 1988 Jan; Vol. 111 (1), pp. 139-47. |
| DOI: |
10.1016/0008-8749(88)90058-5 |
| Abstrakt: |
Class II (Ia) molecules of the major histocompatibility complex are important in the presentation of antigen to T cells and in the regulation of the immune response. Recent studies have suggested that many epithelial cell types can express class II molecules. We examined rat alveolar type II epithelial cells, a cell which can synthesize and secrete pulmonary surface-active material, for the expression of class II antigens. Using an indirect immunofluorescent technique with a mouse anti-rat class II monoclonal antibody (OX-4), the majority of type II cells isolated from pathogen-free Sprague-Dawley rats expressed Ia antigens as determined by fluorescent microscopy and cell sorter analysis. In culture, the Ia expression was lost from type II cells. The addition of recombinant interferon-gamma to cultures of type II cells induced the expression of class II antigens. These findings suggest that class II antigen expression on type II cells may have relevance to immune responses occurring in the lung. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
