| Autor: |
Ahmed M; Department of Chemistry, Maynooth University, Maynooth, County Kildare, Ireland., Rooney D; Department of Chemistry, Maynooth University, Maynooth, County Kildare, Ireland. denise.rooney@mu.ie., McCann M; Department of Chemistry, Maynooth University, Maynooth, County Kildare, Ireland., Devereux M; The Inorganic Pharmaceutical and Biomimetic Research Centre, Focas Research Institute, TU Dublin - City Campus, Kevin Street, Dublin 8, Ireland., Twamley B; School of Chemistry Trinity College Dublin, University of Dublin, Dublin 2, Ireland., Galdino ACM; Department of General Microbiology, Microbiology Institute Paulo de Góes, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil., Sangenito LS; Department of General Microbiology, Microbiology Institute Paulo de Góes, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil., Souza LOP; Department of General Microbiology, Microbiology Institute Paulo de Góes, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil., Lourenço MC; Bacteriology Laboratory, Evandro Chagas Clinical Research Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil., Gomes K; Bacteriology Laboratory, Evandro Chagas Clinical Research Institute, Oswaldo Cruz Foundation, Rio de Janeiro, Brazil., Dos Santos ALS; Department of General Microbiology, Microbiology Institute Paulo de Góes, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil. |
| Abstrakt: |
Hydrazide ligand, (Z)-N'-(6-oxo-1,10-phenanthrolin-5(6H)-ylidene)isonicotinohydrazide, 1 forms from a 1:1 Schiff base condensation reaction between isoniazid (INH) and 1,10-phenanthroline-5,6-dione (phendione). Ag + and Mn 2+ complexes with 1:2 metal:ligand stoichiometry are prepared: [Ag(1) 2 ]NO 3 , [Ag(1) 2 ]BF 4 and [Mn(1) 2 ](NO 3 ) 2 . Polymeric {[Ag(1)(NO 3 )]} n has 1:1 stoichiometry and forms upon infusion of CH 2 Cl 2 into a DMSO solution of [Ag(1) 2 ]NO 3 . {[Ag(1)(NO 3 )]} n was structurally characterized using X-ray crystallography. Metal-free 1 and its 1:2 complexes exhibit very good, broad-spectrum antimicrobial activity and are not excessively toxic to mammalian cells (A549 lineage). |
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