Nonvascularized Bone Grafts for Reconstruction of Segmental Mandibular Defects: Is Length of Graft a Factor of Success?

Autor:	Marechek A; Resident, Department of Oral and Maxillofacial Surgery, Case Western Reserve University, Cleveland, OH. Electronic address: amarechek@gmail.com., AlShare A; Research Fellow, Department of Oral and Maxillofacial Surgery, Case Western Reserve University, Cleveland, OH., Pack S; Private Practitioner, East Lansing, MI; Former Resident, Department of Oral and Maxillofacial Surgery, Case Western Reserve University, Cleveland, OH., Demko C; Statistician, School of Dental Medicine, Case Western Reserve University, Cleveland, OH., Quereshy FA; Professor and Program Director, Department of Oral and Maxillofacial Surgery, Case Western Reserve University, University Hospitals Cleveland Medical Center, Cleveland, OH., Baur D; Professor and Chair, Department of Oral and Maxillofacial Surgery; Vice Dean, CWRU School of Dental Medicine; Division Chief, University Hospitals of Cleveland, Cleveland, OH.
Jazyk:	angličtina
Zdroj:	Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons [J Oral Maxillofac Surg] 2019 Dec; Vol. 77 (12), pp. 2557-2566. Date of Electronic Publication: 2019 May 25.
DOI:	10.1016/j.joms.2019.05.008
Abstrakt:	Purpose: The purpose of this study was to evaluate a long-debated question in the field of whether the success of reconstructing mandibular defects with nonvascularized bone grafts (NVBGs) is dependent on the length of the graft. Materials and Methods: The inclusion criteria were patients who had received NVBGs, such as anterior or posterior iliac crest and costochondral grafts, to reconstruct segmental defects of the mandible between 2008 and 2017 at the Department of Oral and Maxillofacial Surgery at Case Western Reserve University. Patients with a history of irradiation of the head and neck and patients with inadequate follow-up were excluded from this study. Data such as defect length, patient age, comorbidities, length of follow-up, location of defect, etiology of defect, and postoperative course were collected. Success was judged by radiographic and clinical evidence of bone continuity and stability at a minimum of 4 months postoperatively. Failures were considered loss of all or part of the graft, resulting in a residual continuity defect requiring further bone grafting. Results: We identified 61 potential cases, of which 29 met the inclusion and exclusion criteria. The mean age of the patients at the time of grafting was 55 years (range, 17 to 81 years), with a mean follow-up length of 18 months. The length of defects ranged from 2 to 22 cm. The grafts were 6 cm or less in length in 7 defects and greater than 6 cm in length in 22 defects. All cases were grafted at a minimum of 6 months after resection, and bone morphogenetic protein was used in 25 cases (86%). Failure occurred in 1 patient in the group with grafts of 6 cm or less and 2 patients in the group with grafts greater than 6 cm, corresponding to success rates of 86% and 91%, respectively. Eight patients experienced minor complications such as wound dehiscence or infection, which resolved with local measures and antibiotics. Conclusions: The results of our study show that NVBGs are a viable, safe, and effective treatment option for segmental mandibular defects over 6 cm in length in non-irradiated patients. (Copyright © 2019 American Association of Oral and Maxillofacial Surgeons. Published by Elsevier Inc. All rights reserved.)
Databáze:	MEDLINE
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