| Autor: |
Vnukov VV; Southern Federal University, 105/42 B. Sadovaya str., Rostov-on-Don 344006, Russian Federation; e-mail: 89dmitry@mail.ru., Sidorov RV; Rostov State Medical University, 29 Nakhichevan lane, Rostov-on-Don 344022, Russian Federation., Gvaldin DY; Southern Federal University, 105/42 B. Sadovaya str., Rostov-on-Don 344006, Russian Federation; e-mail: 89dmitry@mail.ru., Milyutina NP; Southern Federal University, 105/42 B. Sadovaya str., Rostov-on-Don 344006, Russian Federation; e-mail: 89dmitry@mail.ru., Ananyan AA; Southern Federal University, 105/42 B. Sadovaya str., Rostov-on-Don 344006, Russian Federation; e-mail: 89dmitry@mail.ru., Pospelov DY; Rostov State Medical University, 29 Nakhichevan lane, Rostov-on-Don 344022, Russian Federation., Plotnikov AA; Southern Federal University, 105/42 B. Sadovaya str., Rostov-on-Don 344006, Russian Federation; e-mail: 89dmitry@mail.ru., Shlyk IF; Rostov State Medical University, 29 Nakhichevan lane, Rostov-on-Don 344022, Russian Federation., Dоltmurzieva NS; Rostov State Medical University, 29 Nakhichevan lane, Rostov-on-Don 344022, Russian Federation. |
| Abstrakt: |
76 patients with coronary artery disease who underwent aortocoronary bypass surgery were examined to study the role of paraoxonase, myeloperoxidase, arginase, asymmetric dimethylarginine and nitric oxide in the mechanisms of the pathogenesis of post-pericardiotomy syndrome (PPCS). Patients were divided into two groups: the 1st - patients with coronary artery disease, who did not have PPCS as a result of clinical studies; the 2nd- patients with ischemic heart disease (IHD who were diagnosed with PPCS. The results showed that the postoperative period after coronary artery bypass grafting is associated with inhibition of paraoxonase, activation of myeloperoxidase, increased activity of arginase, nitrite/nitrate level and asymmetric dimethylarginine, and may be accompanied by the development of endothelial dysfunction and increased systemic inflammatory response. In the present work, inverse correlation relationships between the arylesterase activity of paraoxonase and myeloperoxidase activity in plasma, as well as between the aryl esterase activity of paraoxonase in the blood plasma and the activity of arginase in erythrocytes of the patients of the two studied groups were established. tests were developed on basis of ratio of the enzymes activities to predict the development of post-pericardicotomy syndrome. |
