Fucoidans from brown algae Laminaria longipes and Saccharina cichorioides: Structural characteristics, anticancer and radiosensitizing activity in vitro.

Autor: Usoltseva RV; G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, 690022, 159, 100 Let Vladivostoku prosp., Vladivostok, Russian Federation. Electronic address: usoltseva@piboc.dvo.ru., Shevchenko NM; G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, 690022, 159, 100 Let Vladivostoku prosp., Vladivostok, Russian Federation., Malyarenko OS; G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, 690022, 159, 100 Let Vladivostoku prosp., Vladivostok, Russian Federation., Anastyuk SD; G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, 690022, 159, 100 Let Vladivostoku prosp., Vladivostok, Russian Federation., Kasprik AE; G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, 690022, 159, 100 Let Vladivostoku prosp., Vladivostok, Russian Federation., Zvyagintsev NV; G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, 690022, 159, 100 Let Vladivostoku prosp., Vladivostok, Russian Federation., Ermakova SP; G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of the Russian Academy of Sciences, 690022, 159, 100 Let Vladivostoku prosp., Vladivostok, Russian Federation.
Jazyk: angličtina
Zdroj: Carbohydrate polymers [Carbohydr Polym] 2019 Oct 01; Vol. 221, pp. 157-165. Date of Electronic Publication: 2019 May 30.
DOI: 10.1016/j.carbpol.2019.05.079
Abstrakt: The sulfated α-l-fucans ScF and LlF were obtained from brown algae of the Laminariaceae family (Saccharina cichorioides and Laminaria longipes). According to spectroscopy NMR, the LlF fucan predominantly contained the →3)-α-l-Fucp-(2SO 3 -)-(1→4)-α-l-Fucp-(1→2)-α-l-Fucp-(4SO 3 -)-(1→ repeating units, with small amounts of disaccharide 1,4-linked fragments and 3-sulfated fucose residues. Mass spectrometric analysis revealed the presence of the following fragments in the fucan structure: α-l-Fucp-(2SO 3 -)-(1→4)-α-l-Fucp-(2SO 3 -)-(1→3)-α-l-Fucp-(4SO 3 -); α-l-Fucp-(2,4SO 3 -)-(1→3)-α-l-Fucp-(1→3)-α-l-Fucp-(4SO 3 -); α-l-Fucp-(2SO 3 -)-(1→2)-α-l-Fucp; α-l-Fucp-(2SO 3 -)-(1→2)-α-l-Fucp-(4SO 3 -); α-l-Fucp-(2SO 3 -)-(1→3)-α-l-Fucp; α-l-Fucp-(2,4SO 3 -)-(1→3)-α-l-Fucp; α-l-Fucp-(4SO 3 -)-(1→4)-α-l-Fucp; and α-l-Fucp-(4SO 3 -)-(1→4)-α-l-Fucp-(2SO 3 -). Both ScF and LlF fucoidans inhibited colony formation and growth of melanoma and colon cancer cells and sensitize-tested cancer cells to X-ray radiation to a comparable degree.
(Copyright © 2019 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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