Effect of exercise on glucose variability in healthy subjects: randomized crossover trial.

Autor:	Figueira FR; Laboratório de Pesquisa em Fisiopatologia do Exercício, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.; Instituto Federal de Educação, Ciência e Tecnologia do Rio Grande do Sul. Alvorada. Rio Grande do Sul, Brazil., Umpierre D; Laboratório de Pesquisa em Fisiopatologia do Exercício, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.; Nursing School, Universidade Federal do Rio Grande do Sul, Porto Alegre, Rio Grande do Sul, Brazil., Bock PM; Laboratório de Pesquisa em Fisiopatologia do Exercício, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.; Faculdades Integradas de Taquara, Rio Grande do Sul, Brazil.; National Institute of Science and Technology for health Technology Assessment (IATS) - CNPq/Brazil, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil., Waclawovsky G; Laboratório de Pesquisa em Fisiopatologia do Exercício, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil., Guerra AP; Universidade Federal de São Paulo, São Paulo, Brazil., Donelli A; Laboratório de Pesquisa em Fisiopatologia do Exercício, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.; Cardiology Division. Hospital de Clínicas de Porto Alegre. Porto Alegre, Brazil., Andrades M; Unidade de Análises Moleculares e de Proteínas do Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil., Casali KR; Universidade Federal de São Paulo, São Paulo, Brazil., Schaan BD; Laboratório de Pesquisa em Fisiopatologia do Exercício, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.; Endocrine and Cardiology Divisions, Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.; Internal Medicine Department, Faculty of Medicine, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
Jazyk:	angličtina
Zdroj:	Biology of sport [Biol Sport] 2019 Jun; Vol. 36 (2), pp. 141-148. Date of Electronic Publication: 2019 Feb 22.
DOI:	10.5114/biolsport.2019.83006
Abstrakt:	The aim of this study was to evaluate the acute effect of aerobic (AER) and eccentric (ECC) exercise on glucose variability, correlating it with circulating markers of inflammation and oxidative stress in healthy subjects. Sixteen healthy subjects (32 ± 12 years old) wore a continuous glucose monitoring system for three days. Participants randomly performed single AER and ECC exercise sessions. Glucose variability was evaluated by glucose variance (VAR), glucose coefficient of variation (CV%) and glucose standard deviation (SD). Blood samples were collected to evaluate inflammatory and oxidative stress markers. When compared with the pre-exercise period of 0-6 h, all the indices of glucose variability presented comparable reductions 12-18 h after both exercises (∆AER: VAR= 151.5, ∆CV% = 0.55 and ∆SD = 3.1 and ECC: ∆VAR = 221.2 , ∆CV% = 3.7 and ∆SD = 6.5). Increased interleukin-6 (IL-6) levels after AER (68.5%) and ECC (30.8%) (P<0.001) were observed, with no differences between sessions (P = 0.459). Uric acid levels were increased after exercise sessions (3% in AER and 4% in ECC, P = 0.001). In conclusion, both AER and ECC exercise sessions reduced glucose variability in healthy individuals. Inflammatory cytokines, such as IL-6, and stress oxidative markers might play a role in underlying mechanisms modulating the glucose variability responses to exercise (clinicalTrials.gov NCT02262208). Competing Interests: All other authors have no conflict of interest to declare.
Databáze:	MEDLINE
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