| Autor: |
Pereira FDSCF; Department of Neurology, Graduate Program in Neurology (PPGNEURO) - Universidade Federal do Estado do Rio de Janeiro, UNIRIO, Rio de Janeiro, RJ, 20270-004, Brazil. fabiana.pereira@unirio.br., Guimarães RM; Research Center for Population and Public Policies Studies, Rio de Janeiro, Brazil. Oswaldo Cruz Foundation, Rio de Janeiro, RJ, 21040-900, Brazil., Lucidi AR; Department of Neurology, Graduate Program in Neurology (PPGNEURO) - Universidade Federal do Estado do Rio de Janeiro, UNIRIO, Rio de Janeiro, RJ, 20270-004, Brazil., Brum DG; Departamento de Neurologia, Psicologia e Psiquiatria, Faculdade de Medicina de Botucatu, Universidade Estadual Paulista -UNESP, Botucatu, São Paulo, Brazil., Paiva CLA; Department of Neurology, Graduate Program in Neurology (PPGNEURO) - Universidade Federal do Estado do Rio de Janeiro, UNIRIO, Rio de Janeiro, RJ, 20270-004, Brazil.; Department of Genetics and Molecular Biology, UNIRIO, Rio de Janeiro, 20211-010, RJ, Brazil.; Graduate Program in Molecular and Cell Biology (PPGBMC). UNIRIO, Rio de Janeiro, RJ, 20211-010, Brazil., Alvarenga RMP; Department of Neurology, Graduate Program in Neurology (PPGNEURO) - Universidade Federal do Estado do Rio de Janeiro, UNIRIO, Rio de Janeiro, RJ, 20270-004, Brazil. |
| Abstrakt: |
The variables such as race, skin colour and ethnicity have become intensely discussed in medicine research, as a response to the rising debate over the importance of the ethnic-racial dimension in the scope of health-disease processes. The aim of this study was to identify the European (EUR), African (AFR) and Amerindian (AMR) ancestries on Brazilian health outcomes through a systematic literature review. This study was carried out by searching in three electronic databases, for studies published between 2005 and 2017. A total of 13 papers were eligible. The search identified the following health outcomes: visceral leishmaniosis, malaria, Alzheimer's disease, neuromyelitis optica, multiple sclerosis, prostate cancer, non-syndromic cleft lip/palate, chronic heart failure, sickle cell disease, primary congenital glaucoma, preterm labour, preterm premature rupture of membranes, systemic lupus erythematosus and type 1 diabetes mellitus. Research paper assessments were guided by the STROBE instrument, and agreements between results were determined by comparing the points attributed by two authors. Increased EUR ancestry was identified from preterm labour (PTL), type 1 diabetes (T1D) and non-syndromic cleft lip with or without cleft palate (NSCL), as well as in patients presenting aggressive prostate cancer prognoses. On the other hand, the highest AFR ancestral component was verified from systemic lupus erythematosus (SLE) and primary congenital glaucoma (PCG) cases, presenting worse prognoses. AMR ancestry may be a protective factor in the development of Alzheimer's disease (AD). The worst hemodynamic parameters in cases of heart failure (HF) were identified among individuals with greater AMR and AFR ancestry indices. |
