Heritability analysis of nontraditional glycemic biomarkers in the Atherosclerosis Risk in Communities Study.

Autor: Loomis SJ; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland., Tin A; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland., Coresh J; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.; Welch Center for Prevention, Epidemiology, & Clinical Research, The Johns Hopkins University, Baltimore, Maryland., Boerwinkle E; Department of Epidemiology, The University of Texas Health Science Center at Houston School of Public Health at Houston, Houston, Texas., Pankow JS; Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, Minnesota., Köttgen A; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.; Medical Center and Faculty of Medicine, Institute of Genetic Epidemiology, University of Freiburg, Freiburg, Germany., Selvin E; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.; Welch Center for Prevention, Epidemiology, & Clinical Research, The Johns Hopkins University, Baltimore, Maryland., Duggal P; Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland.
Jazyk: angličtina
Zdroj: Genetic epidemiology [Genet Epidemiol] 2019 Oct; Vol. 43 (7), pp. 776-785. Date of Electronic Publication: 2019 Jun 19.
DOI: 10.1002/gepi.22243
Abstrakt: Nontraditional glycemic biomarkers, including fructosamine, glycated albumin, and 1,5-anhydroglucitol (1,5-AG) are potential alternatives or complement to traditional measures of hyperglycemia. Genetic variants are associated with these biomarkers, but the heritability, or extent to which genetics control their variation, is not known. We estimated pedigree-based, SNP-based, and bivariate heritabilities for traditional glycemic biomarkers (fasting glucose, HbA1c), and nontraditional biomarkers (fructosamine, glycated albumin, 1,5-AG) among white participants in the Atherosclerosis Risk in Communities (ARIC) Study (N = 400 first-degree relatives from sibships, N = 5,575 unrelated individuals). Pedigree-based heritabilities (representing heritability from the entire genome) for nontraditional biomarkers were substantial (0.44-0.55) and comparable to HbA1c (0.34); the fasting glucose estimate was nonsignificant. SNP-based heritabilities (representing heritability from common variants) were lower than pedigree-based heritabilities for all biomarkers. Bivariate heritabilities showed shared genetics between fructosamine and glycated albumin (0.46 pedigree-based, 1.00 SNP-based) and glycated albumin and 1,5-AG (0.50 pedigree-based, 0.47 SNP-based). Genetic factors contribute to a considerable proportion of the variance of fructosamine, glycated albumin, and 1,5-AG and a portion of this heritability likely comes from common variants.
(© 2019 Wiley Periodicals, Inc.)
Databáze: MEDLINE
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