Eosinophilic granulomatosis with polyangiitis in a Nigerian woman.

Autor:	Ekeigwe NL; Department of Internal Medicine, Federal Medical Center Owerri, Owerri, Nigeria., Adelowo O; Department of Medicine, Lagos State University Teaching Hospital, Lagos, Nigeria., Anaba EL; Department of Medicine, Lagos State University Teaching Hospital, Lagos, Nigeria., Olaosebikan H; Department of Medicine, Lagos State University Teaching Hospital, Lagos, Nigeria.
Jazyk:	angličtina
Zdroj:	BMJ case reports [BMJ Case Rep] 2019 Jun 18; Vol. 12 (6). Date of Electronic Publication: 2019 Jun 18.
DOI:	10.1136/bcr-2018-228901
Abstrakt:	Eosinophilic granulomatosis with polyangiitis (EGPA), previously called Churg-Strauss Syndrome, is a systemic autoimmune disease that is usually associated with asthma and eosinophilia. It is a rare condition associated with antineutrophil cytoplasmic antibodies (ANCA). We report a case of a 52-year-old Nigerian woman who presented with bilateral leg swelling with multiple ulcers, background history of allergic rhinitis and chronic sinusitis since adolescence. There were also associated symptoms of peripheral neuropathy, weight loss, peripheral blood eosinophilia and positive perinuclear ANCA and she was previously managed for rheumatoid arthritis and asthma. She fulfilled the American College of Rheumatology criteria for EGPA and was treated with glucocorticoids and methotrexate which led to significant improvement of her symptoms. Competing Interests: Competing interests: None declared. (© BMJ Publishing Group Limited 2019. No commercial re-use. See rights and permissions. Published by BMJ.)
Databáze:	MEDLINE
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