[Complex assessment of retinal ischemic damage in patients with retinal vein occlusion].

Autor:	Zlobin IV; Irkutsk branch of S. Fyodorov Eye Microsurgery Federal State Institution, 337 Lermontova St., Irkutsk, Russian Federation, 664033., Zhukova SI; Irkutsk branch of S. Fyodorov Eye Microsurgery Federal State Institution, 337 Lermontova St., Irkutsk, Russian Federation, 664033., Shchuko AG; Irkutsk branch of S. Fyodorov Eye Microsurgery Federal State Institution, 337 Lermontova St., Irkutsk, Russian Federation, 664033; Irkutsk State Medical Academy of Postgraduate Education, 100 Yubileiny microrayon, Irkutsk, Russian Federation, 664079; Irkutsk State Medical University, 1 Krasnogo Vosstaniya St., Irkutsk, Russian Federation, 664003., Iureva TN; Irkutsk branch of S. Fyodorov Eye Microsurgery Federal State Institution, 337 Lermontova St., Irkutsk, Russian Federation, 664033; Irkutsk State Medical Academy of Postgraduate Education, 100 Yubileiny microrayon, Irkutsk, Russian Federation, 664079; Irkutsk State Medical University, 1 Krasnogo Vosstaniya St., Irkutsk, Russian Federation, 664003.
Jazyk:	ruština
Zdroj:	Vestnik oftalmologii [Vestn Oftalmol] 2019; Vol. 135 (2), pp. 62-69.
DOI:	10.17116/oftalma201913502162
Abstrakt:	Purpose: To evaluate the effectiveness of treatment and the possibility of restoring visual functions in patients with retinal vein occlusion (RVO) depending on the initial degree of macular ischemia. Material and Methods: The study included 84 patients with RVO. The main inclusion criteria were the presence of macular edema in the setting of RVO with the duration of no more than 3 months and without any previous treatment. All patients underwent intravitreal injections of an angiogenesis inhibitor, followed by laser treatment when necessary. A comparative analysis of the results was carried out in groups that were opposite in terms of the clinical effect - before the start of the therapy, after 1 month, and after 12 months. All patients and the control group members underwent standard ophthalmological examination as well as electroretinography, fluorescence angiography, optical coherence tomography (OCT), and OCT angiography. Results: Based on data obtained during 12 months of the follow-up, the comparative analysis of the initial ophthalmic status of patients with RVO with opposite clinical effect resulted in derivation of 3 clinical groups that correspond to the degrees of macular ischemia - mild, moderate and severe. Conclusion: Determination of the degree of macular ischemia at the stage of primary diagnosis can improve the treatment effectiveness and inform the patients about the sequence and duration of anti-VEGF therapy. Intravitreal injections of ranibizumab in retinal vein occlusion are carried out before the elimination of macular edema and further in the on-demand mode, while the number of injections can vary from one to monthly injections during the year.
Databáze:	MEDLINE
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