Family history of Alzheimer's disease alters cognition and is modified by medical and genetic factors.

Autor:	Talboom JS; The Translational Genomics Research Institute, Phoenix, United States.; Arizona Alzheimer's Consortium, Phoenix, United States., Håberg A; Norwegian University of Science and Technology, Trondheim, Norway., De Both MD; The Translational Genomics Research Institute, Phoenix, United States.; Arizona Alzheimer's Consortium, Phoenix, United States., Naymik MA; The Translational Genomics Research Institute, Phoenix, United States.; Arizona Alzheimer's Consortium, Phoenix, United States., Schrauwen I; The Translational Genomics Research Institute, Phoenix, United States.; Arizona Alzheimer's Consortium, Phoenix, United States., Lewis CR; The Translational Genomics Research Institute, Phoenix, United States.; Arizona Alzheimer's Consortium, Phoenix, United States., Bertinelli SF; The Translational Genomics Research Institute, Phoenix, United States., Hammersland C; The Translational Genomics Research Institute, Phoenix, United States., Fritz MA; The Translational Genomics Research Institute, Phoenix, United States., Myers AJ; University of Miami, Miami, United States., Hay M; Arizona Alzheimer's Consortium, Phoenix, United States.; University of Arizona, Tucson, United States., Barnes CA; Arizona Alzheimer's Consortium, Phoenix, United States.; University of Arizona, Tucson, United States., Glisky E; Arizona Alzheimer's Consortium, Phoenix, United States.; University of Arizona, Tucson, United States., Ryan L; Arizona Alzheimer's Consortium, Phoenix, United States.; University of Arizona, Tucson, United States., Huentelman MJ; The Translational Genomics Research Institute, Phoenix, United States.; Arizona Alzheimer's Consortium, Phoenix, United States.
Jazyk:	angličtina
Zdroj:	ELife [Elife] 2019 Jun 18; Vol. 8. Date of Electronic Publication: 2019 Jun 18.
DOI:	10.7554/eLife.46179
Abstrakt:	In humans, a first-degree family history of dementia (FH) is a well-documented risk factor for Alzheimer's disease (AD); however, the influence of FH on cognition across the lifespan is poorly understood. To address this issue, we developed an internet-based paired-associates learning (PAL) task and tested 59,571 participants between the ages of 18-85. FH was associated with lower PAL performance in both sexes under 65 years old. Modifiers of this effect of FH on PAL performance included age, sex, education, and diabetes. The Apolipoprotein E ε4 allele was also associated with lower PAL scores in FH positive individuals. Here we show, FH is associated with reduced PAL performance four decades before the typical onset of AD; additionally, several heritable and non-heritable modifiers of this effect were identified. Competing Interests: JT, AH, MD, MN, IS, CL, SB, CH, MF, AM, MH, CB, EG, LR, MH No competing interests declared (© 2019, Talboom et al.)
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu