| Autor: |
Garcia-Egan PM; Department of Psychological Sciences, University of Missouri, St. Louis, MO, 63121, USA., Preston-Campbell RN; Missouri Institute of Mental Health, St. Louis, MO, 63134, USA., Salminen LE; Imaging Genetics Center, Stevens Neuroimaging and Informatics Institute, University of Southern California, Marina del Rey, CA, 90292, USA., Heaps-Woodruff JM; Missouri Institute of Mental Health, St. Louis, MO, 63134, USA., Balla L; Missouri Institute of Mental Health, St. Louis, MO, 63134, USA., Cabeen RP; Laboratory of Neuro Imaging, Stevens Neuroimaging and Informatics Institute, Keck School of Medicine of USC, University of Southern California, LosAngeles, CA, 90033, USA., Laidlaw DH; Department of Computer Science, Brown University, Providence, RI, 02906, USA., Conturo TE; Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, 63110, USA., Paul RH; Department of Psychological Sciences, University of Missouri, St. Louis, MO, 63121, USA. paulro@umsl.edu.; Missouri Institute of Mental Health, St. Louis, MO, 63134, USA. paulro@umsl.edu. |
| Abstrakt: |
Little is known about the contribution of white matter integrity to inhibitory cognitive control, particularly in healthy aging. The present study examines the correspondence between white matter fiber bundle length and behavioral inhibition in 37 community-dwelling older adults (aged 51-78 years). Participants underwent neuroimaging with 3 Tesla MRI, and completed a behavioral test of inhibition (i.e., Go/NoGo task). Quantitative tractography derived from diffusion tensor imaging (qtDTI) was used to measure white matter fiber bundle lengths (FBLs) in tracts known to innervate frontal brain regions, including the anterior corpus callosum (AntCC), the cingulate gyrus segment of the cingulum bundle (CING), uncinate fasciculus (UNC), and the superior longitudinal fasciculus (SLF). Performance on the Go/NoGo task was measured by the number of commission errors standardized to reaction time. Hierarchical regression models revealed that shorter FBLs in the CING (p < 0.05) and the bilateral UNC (p < 0.01) were associated with lower inhibitory performance after adjusting for multiple comparisons, supporting a disconnection model of response inhibition in older adults. Prospective longitudinal studies are needed to examine the evolution of inhibitory errors in older adult populations and potential for therapeutic intervention. |
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