The Alzheimer's Disease-Associated Protein BACE1 Modulates T Cell Activation and Th17 Function.
| Autor: | Hernandez-Mir G; Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15261; and., Raphael I; Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15261; and., Revu S; Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15261; and., Poholek CH; Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15261; and., Avery L; Department of Immunology, University of Pittsburgh, Pittsburgh, PA 15261., Hawse WF; Department of Immunology, University of Pittsburgh, Pittsburgh, PA 15261., Kane LP; Department of Immunology, University of Pittsburgh, Pittsburgh, PA 15261., McGeachy MJ; Division of Rheumatology and Clinical Immunology, Department of Medicine, University of Pittsburgh, Pittsburgh, PA 15261; and mandymcgeachy@pitt.edu. |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | Journal of immunology (Baltimore, Md. : 1950) [J Immunol] 2019 Aug 01; Vol. 203 (3), pp. 665-675. Date of Electronic Publication: 2019 Jun 17. |
| DOI: | 10.4049/jimmunol.1800363 |
| Abstrakt: | β-site amyloid precursor protein-cleaving enzyme 1 (BACE1) is best known for its role in Alzheimer's disease amyloid plaque formation but also contributes to neurodegenerative processes triggered by CNS injury. In this article, we report that BACE1 is expressed in murine CD4 + T cells and regulates signaling through the TCR. BACE1-deficient T cells have reduced IL-17A expression under Th17 conditions and reduced CD73 expression in Th17 and inducible T regulatory cells. However, induction of the Th17 and T regulatory transcription factors RORγt and Foxp3 was unaffected. BACE1-deficient T cells showed impaired pathogenic function in experimental autoimmune encephalomyelitis. These data identify BACE1 as a novel regulator of T cell signaling pathways that impact autoimmune inflammatory T cell function. (Copyright © 2019 by The American Association of Immunologists, Inc.) |
| Databáze: | MEDLINE |
| Externí odkaz: |
|