Association of Human Papillomavirus Genotype 16 Viral Variant and Viral Load with Cervical High-grade Intraepithelial Lesions.
| Autor: | Álvarez-Paredes L; Department of Microbiology and Parasitology, University Hospital of Burgos, Burgos, Spain., Santibañez M; Department of Nursing, Nursing Research Group-IDIVAL, University of Cantabria, Cantabria, Spain., Galiana A; Department of Microbiology, University General Hospital of Elche, Alicante, Spain., Rodríguez Díaz JC; Department of Microbiology, University General Hospital of Alicante, Alicante, Spain., Parás-Bravo P; Department of Nursing, Nursing Research Group-IDIVAL, University of Cantabria, Cantabria, Spain., Andrada-Becerra ME; Department of Pathological Anatomy, University General Hospital of Elche, Alicante, Spain., Ruiz García MM; Department of Microbiology, University General Hospital of Elche, Alicante, Spain., Rodríguez-Ingelmo JM; Department of Gynecology, University General Hospital of Elche, Alicante, Spain., Portilla-Sogorb J; Department of Infectious Diseases, University Hospital of Alicante, Alicante, Spain., Paz-Zulueta M; Department of Nursing, University of Cantabria, Cantabria, Spain. IDIVAL, GI Derecho Sanitario y Bioetica, GRIDES, Cantabria, Spain. maria.paz@unican.es. |
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| Jazyk: | angličtina |
| Zdroj: | Cancer prevention research (Philadelphia, Pa.) [Cancer Prev Res (Phila)] 2019 Aug; Vol. 12 (8), pp. 547-556. Date of Electronic Publication: 2019 Jun 17. |
| DOI: | 10.1158/1940-6207.CAPR-18-0397 |
| Abstrakt: | Human papillomavirus genotype 16 (HPV16) is by far the genotype most strongly associated with cervical cancer; viral variant and/or viral load of HPV16 could modulate this association. The objective was to determine the association between the viral variant and viral load of HPV16 and the presence of cervical high-grade lesions. This cross-sectional study included all women in whom HPV infection was found by cervical smear during routine gynecologic health checks. Women with single or multiple HPV16 infections ( n = 176) were selected for viral variant and viral load analysis. Smear results were classified using the Bethesda system. HPV types were classified according to the International Agency for Research on Cancer. Odds ratios (OR) with their 95% confidence intervals (CI) were estimated by logistic regression, adjusted for age, immigrant status, and coinfection with other high-risk genotypes. No statistically significant associations were found regarding the detected viral variants. A viral load above the median (>1,367.79 copies/cell) was associated with a significant risk of high-grade epithelial lesion or carcinoma, after adjusting for age, immigrant status, coinfections, and viral variant: (adjusted OR 7.89; 95% CI: 2.75-22.68). This relationship showed a statistically significant dose-response pattern after categorizing by viral load tertiles: adjusted OR for a viral load greater than the third tertile was 17.23 (95% CI: 4.20-70.65), with adjusted linear P (©2019 American Association for Cancer Research.) |
| Databáze: | MEDLINE |
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