Benzophenones from Anemarrhena asphodeloides Bge. Exhibit Anticancer Activity in HepG2 Cells via the NF-κB Signaling Pathway.

Autor: Wu DL; Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, China. dlwu7375@sina.com.; School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China. dlwu7375@sina.com.; Anhui Province Key Laboratory of Traditional Chinese Medicine Decoction Pieces of New Manufacturing Technology, Anhui University of Chinese Medicine, Hefei 230012, China. dlwu7375@sina.com., Liao ZD; School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China. yyfhzwz@163.com., Chen FF; School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China. rtsjxfc@163.com., Zhang W; School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China. zhangwei@ahtcm.edu.cn.; Anhui Province Key Laboratory of Traditional Chinese Medicine Decoction Pieces of New Manufacturing Technology, Anhui University of Chinese Medicine, Hefei 230012, China. zhangwei@ahtcm.edu.cn., Ren YS; School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China. renyashuo@gmail.com.; Anhui Province Key Laboratory of Traditional Chinese Medicine Decoction Pieces of New Manufacturing Technology, Anhui University of Chinese Medicine, Hefei 230012, China. renyashuo@gmail.com., Wang CC; School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China. cancanW1120@163.com., Chen XX; School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China. 15077919652@163.com., Peng DY; School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012, China. pengdaiyin@163.com., Kong LY; Jiangsu Key Laboratory of Bioactive Natural Product Research and State Key Laboratory of Natural Medicines, School of Traditional Chinese Pharmacy, China Pharmaceutical University, 24 Tong Jia Xiang, Nanjing 210009, China. cpu_lykong@126.com.
Jazyk: angličtina
Zdroj: Molecules (Basel, Switzerland) [Molecules] 2019 Jun 15; Vol. 24 (12). Date of Electronic Publication: 2019 Jun 15.
DOI: 10.3390/molecules24122246
Abstrakt: A chemical investigation of the fibrous roots of Anemarrhena asphodeloides Bge. led to the isolation of four benzophenones, including one new compound ( 1 ) and three known ones ( 2-4 ). Comprehensive 1 D, 2 D NMR and HRESIMS data established the structures of the isolated compounds. The absolute configurations were determined by comparison of the calculated optical rotation (OR) with experimental data. All the isolates were evaluated for their cytotoxicities on hepatocellular carcinoma cell lines (HepG2 and Hep3B). Compound 1 showed strong cytotoxicity against HepG2 and Hep3B cells, with IC 50 values at 153.1 and 180.6 nM. Through MTT assay, flow cytometry and Western blot analysis, compound 1 demonstrated the ability to stimulate apoptosis via the NF-κB signaling pathway in HepG2 cells. These benzophenones are potential lead compounds for the development of better treatments for hepatocellular carcinoma.
Databáze: MEDLINE
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