Infectious episodes during pregnancy, at particular mucosal sites, increase specific IgA1 or IgA2 subtype levels in human colostrum.

Autor: Sánchez-Salguero E; 1Department of Molecular Biomedicine, Center for Research and Advanced Studies (CINVESTAV), National Polytechnic Institute (IPN), Mexico City, Mexico., Mondragón-Ramírez GK; 1Department of Molecular Biomedicine, Center for Research and Advanced Studies (CINVESTAV), National Polytechnic Institute (IPN), Mexico City, Mexico.; 2Interdisciplinary Center for Health Sciences, Milpa Alta Unit (CICSUMA), National Polytechnic Institute (IPN), Mexico City, Mexico., Alcántara-Montiel JC; School of Higher Studies Zaragoza, National Autonomous University of Mexico (UNAM), Regional Hospital of High Specialty of Ixtapaluca (HRAEI), Mexico City, Mexico., Cérbulo-Vázquez A; 4Faculty of Medicine, Plan of Combined Studies in Medicine (PECEM), National Autonomous University of Mexico (UNAM), Mexico City, Mexico.; 5Women's Hospital, Ministry of Health (SSA), Mexico City, Mexico., Villegas-Domínguez X; 5Women's Hospital, Ministry of Health (SSA), Mexico City, Mexico., Contreras-Vargas VM; 6Departments of Gynecology and Genomic Medicine, Regional Hospital 1° de Octubre, Institute of Security and Social Services of State Workers (ISSSTE), Mexico City, Mexico., Thompson-Bonilla MDR; 6Departments of Gynecology and Genomic Medicine, Regional Hospital 1° de Octubre, Institute of Security and Social Services of State Workers (ISSSTE), Mexico City, Mexico., Romero-Ramírez H; 1Department of Molecular Biomedicine, Center for Research and Advanced Studies (CINVESTAV), National Polytechnic Institute (IPN), Mexico City, Mexico., Santos-Argumedo L; 1Department of Molecular Biomedicine, Center for Research and Advanced Studies (CINVESTAV), National Polytechnic Institute (IPN), Mexico City, Mexico.
Jazyk: angličtina
Zdroj: Maternal health, neonatology and perinatology [Matern Health Neonatol Perinatol] 2019 Jun 11; Vol. 5, pp. 9. Date of Electronic Publication: 2019 Jun 11 (Print Publication: 2019).
DOI: 10.1186/s40748-019-0104-x
Abstrakt: Background: Colostrum is the primary source of maternal immunoglobulin A (IgA) for the newborn. IgA participates in protection and regulation mechanisms of the immune response at the neonate's mucosa. Several studies have evaluated infectious diseases and vaccine protocols effects during pregnancy on maternal milk IgA levels, with the aim to understand lactation protecting effect on newborn. However, most of their results demonstrated that there were no differences in the total IgA levels. In humans, IgA has two subclasses (IgA1 and IgA2), they have an anatomical distribution among mucosal compartments, their levels vary after antigen stimulation and are also seen to describe differential affinities in colostrum. Although there are differences between IgA subclasses in several compartments, these studies have excluded specific colostrum IgA1 and IgA2 determination.
Methods: We analyzed data from 900 women in Mexico City. With Pearson correlation, we compared the number of infectious episodes during their pregnancy that was associated with mucosal compartments (skin, respiratory and gastrointestinal tracts) and colostrum IgA subclasses.
Results: We show a correlation between increased colostrum IgA1 levels and the number of infectious episodes at respiratory tract and the skin. In contrast, infections at the gastrointestinal tract correlated with increased IgA2 amounts.
Conclusions: I nfections present during pregnancy at certain mucosal site increase specific IgA subclasses levels in human colostrum. These results will help in understanding infections and immunizations effects on maternal IgA at the mammary gland, and their impact on the development and protection of the newborn.
Competing Interests: Competing interestsNo potential conflict of interest was reported by the authors.
Databáze: MEDLINE
Externí odkaz: