Performance of 18F-FDG, 11C-Methionine, and 18F-FET PET for Glioma Grading: A Meta-analysis.

Autor:	Katsanos AH; From the Department of Neurology, St. Josef Hospital, Ruhr University of Bochum, Bochum, Germany.; Neurosurgical Research Institute, University of Ioannina., Alexiou GA; Neurosurgical Research Institute, University of Ioannina.; Departments of Neurosurgery., Fotopoulos AD; Nuclear Medicine, University of Ioannina School of Medicine, Ioannina, Greece., Jabbour P; Division of Neurovascular Surgery and Endovascular Neurosurgery, Thomas Jefferson University Hospital, Philadelphia, PA., Kyritsis AP; Neurosurgical Research Institute, University of Ioannina.; Department of Neurology, University of Ioannina School of Medicine, Ioannina, Greece., Sioka C; Neurosurgical Research Institute, University of Ioannina.; Division of Neurovascular Surgery and Endovascular Neurosurgery, Thomas Jefferson University Hospital, Philadelphia, PA.
Jazyk:	angličtina
Zdroj:	Clinical nuclear medicine [Clin Nucl Med] 2019 Nov; Vol. 44 (11), pp. 864-869.
DOI:	10.1097/RLU.0000000000002654
Abstrakt:	Purpose: Gliomas constitute the most frequent primary brain tumors. Glioblastoma, the most common and malignant glioma in adults, has dismal prognosis with any current therapy. On the other hand, low-grade gliomas, the second most common type of gliomas, are potentially curative with appropriate treatment. Methods: We conducted a meta-analysis to assess the performance of PET tracers with the best available evidence, namely, fluorodeoxyglucose (FDG), C-methionine (MET), and F-fluoroethyltyrosine (FET), in differentiating low- from high-grade gliomas. Results: Twenty-three studies with a total of 994 participants were included in this meta-analysis. The pooled sensitivities of both MET PET and FET PET were found to be significantly higher than of FDG PET (94%, 88%, and 63% respectively, P < 0.001). The pooled specificity of FDG PET was found to be significantly greater compared with both MET PET and FET PET (89%, 55%, and 57%, respectively; P = 0.002). Fluorodeoxyglucose PET was superior in terms of higher positive likelihood ratio values compared with both FET PET and MET PET. Conclusions: This meta-analysis indicated that both MET and FET were superior to FDG in terms of sensitivity for identifying glioma grade.
Databáze:	MEDLINE
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