Acetic acid activates distinct taste pathways in Drosophila to elicit opposing, state-dependent feeding responses.

Autor: Devineni AV; Department of Neuroscience, The Mortimer B Zuckerman Mind Brain Behavior Institute, Columbia University, New York, United States., Sun B; Department of Neuroscience, The Mortimer B Zuckerman Mind Brain Behavior Institute, Columbia University, New York, United States., Zhukovskaya A; Department of Neuroscience, The Mortimer B Zuckerman Mind Brain Behavior Institute, Columbia University, New York, United States., Axel R; Department of Neuroscience, The Mortimer B Zuckerman Mind Brain Behavior Institute, Columbia University, New York, United States.; Howard Hughes Medical Institute, Columbia University, New York, United States.
Jazyk: angličtina
Zdroj: ELife [Elife] 2019 Jun 17; Vol. 8. Date of Electronic Publication: 2019 Jun 17.
DOI: 10.7554/eLife.47677
Abstrakt: Taste circuits are genetically determined to elicit an innate appetitive or aversive response, ensuring that animals consume nutritious foods and avoid the ingestion of toxins. We have examined the response of Drosophila melanogaster to acetic acid, a tastant that can be a metabolic resource but can also be toxic to the fly. Our data reveal that flies accommodate these conflicting attributes of acetic acid by virtue of a hunger-dependent switch in their behavioral response to this stimulus. Fed flies show taste aversion to acetic acid, whereas starved flies show a robust appetitive response. These opposing responses are mediated by two different classes of taste neurons, the sugar- and bitter-sensing neurons. Hunger shifts the behavioral response from aversion to attraction by enhancing the appetitive sugar pathway as well as suppressing the aversive bitter pathway. Thus a single tastant can drive opposing behaviors by activating distinct taste pathways modulated by internal state.
Competing Interests: AD, BS, AZ, RA No competing interests declared
(© 2019, Devineni et al.)
Databáze: MEDLINE
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