A pyrazole-containing hydrazone for fluorescent imaging of Al 3+ in lysosomes and its resultant Al 3+ complex as a sensor for F .

Autor: Wang Y; College of Chemistry and Chemical Engineering, Henan Polytechnic University, Jiaozuo, 454000, PR China., Song YF; College of Chemistry and Chemical Engineering, Henan Polytechnic University, Jiaozuo, 454000, PR China., Zhang L; College of Chemistry and Chemical Engineering, Henan Polytechnic University, Jiaozuo, 454000, PR China., Dai GG; College of Chemistry and Chemical Engineering, Henan Polytechnic University, Jiaozuo, 454000, PR China., Kang RF; College of Chemistry and Chemical Engineering, Henan Polytechnic University, Jiaozuo, 454000, PR China., Wu WN; College of Chemistry and Chemical Engineering, Henan Polytechnic University, Jiaozuo, 454000, PR China. Electronic address: wuwn08@hpu.edu.cn., Xu ZH; Key Laboratory of Chemo/Biosensing and Detection, School of Chemistry and Chemical Engineering, Xuchang University, 461000, PR China; College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou, 450052, PR China. Electronic address: xuzhihong1980@xcu.edu.cn., Fan YC; College of Chemistry and Chemical Engineering, Henan Polytechnic University, Jiaozuo, 454000, PR China., Bian LY; College of Chemistry and Chemical Engineering, Henan Polytechnic University, Jiaozuo, 454000, PR China.
Jazyk: angličtina
Zdroj: Talanta [Talanta] 2019 Oct 01; Vol. 203, pp. 178-185. Date of Electronic Publication: 2019 May 14.
DOI: 10.1016/j.talanta.2019.05.051
Abstrakt: A fluorescence-enhanced and lysosome-targeted Al 3+ probe (1) based on a pyrazole-containing hydrazone was developed in this work. The fluorescent probe 1 displays an OFF-ON fluorescence response to Al 3+ in the lysosome pH environment. In addition, the resultant 1-Al 3+ complex could act as an ON-OFF fluorescence sensor for F - . Fluorescence imaging shows that 1 is suitable for visualization of Al 3+ in lysosomes of HeLa cells.
(Copyright © 2019 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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