Deterministic processes structure bacterial genetic communities across an urban landscape.

Autor:	Hassell JM; Institute of Infection and Global Health, University of Liverpool, Leahurst Campus, Chester High Road, Neston, CH64 7TE, UK. hassell.jm@gmail.com.; International Livestock Research Institute, 30709, Nairobi, Kenya. hassell.jm@gmail.com., Ward MJ; Centre for Immunity, Infection and Evolution, University of Edinburgh, EH9 3FL, Edinburgh, UK.; Nuffield Department of Clinical Medicine, University of Oxford, John Radcliffe Hospital, OX3 9DU, Oxford, UK., Muloi D; International Livestock Research Institute, 30709, Nairobi, Kenya.; Centre for Immunity, Infection and Evolution, University of Edinburgh, EH9 3FL, Edinburgh, UK.; Usher Institute of Population Health Sciences & Informatics, University of Edinburgh, EH16 4UX, Edinburgh, UK., Bettridge JM; Institute of Infection and Global Health, University of Liverpool, Leahurst Campus, Chester High Road, Neston, CH64 7TE, UK.; International Livestock Research Institute, 30709, Nairobi, Kenya., Phan H; Nuffield Department of Clinical Medicine, University of Oxford, John Radcliffe Hospital, OX3 9DU, Oxford, UK.; Faculty of Medicine, NIHR BRC Southampton, University of Southampton, SO16 6YD, Southampton, UK., Robinson TP; Food and Agriculture Organization of the United Nations, 00153, Rome, Italy., Ogendo A; International Livestock Research Institute, 30709, Nairobi, Kenya., Imboma T; National Museums of Kenya, 40658, Nairobi, Kenya., Kiiru J; Kenya Medical Research Institute, 54840, Nairobi, Kenya., Kariuki S; Kenya Medical Research Institute, 54840, Nairobi, Kenya., Begon M; Institute of Integrative Biology, University of Liverpool, Liverpool, L69 7ZB, UK., Kang'ethe EK; University of Nairobi, 29053, Nairobi, Kenya., Woolhouse MEJ; Centre for Immunity, Infection and Evolution, University of Edinburgh, EH9 3FL, Edinburgh, UK.; Usher Institute of Population Health Sciences & Informatics, University of Edinburgh, EH16 4UX, Edinburgh, UK., Fèvre EM; Institute of Infection and Global Health, University of Liverpool, Leahurst Campus, Chester High Road, Neston, CH64 7TE, UK. Eric.Fevre@liverpool.ac.uk.; International Livestock Research Institute, 30709, Nairobi, Kenya. Eric.Fevre@liverpool.ac.uk.
Jazyk:	angličtina
Zdroj:	Nature communications [Nat Commun] 2019 Jun 14; Vol. 10 (1), pp. 2643. Date of Electronic Publication: 2019 Jun 14.
DOI:	10.1038/s41467-019-10595-1
Abstrakt:	Land-use change is predicted to act as a driver of zoonotic disease emergence through human exposure to novel microbial diversity, but evidence for the effects of environmental change on microbial communities in vertebrates is lacking. We sample wild birds at 99 wildlife-livestock-human interfaces across Nairobi, Kenya, and use whole genome sequencing to characterise bacterial genes known to be carried on mobile genetic elements (MGEs) within avian-borne Escherichia coli (n = 241). By modelling the diversity of bacterial genes encoding virulence and antimicrobial resistance (AMR) against ecological and anthropogenic forms of urban environmental change, we demonstrate that communities of avian-borne bacterial genes are shaped by the assemblage of co-existing avian, livestock and human communities, and the habitat within which they exist. In showing that non-random processes structure bacterial genetic communities in urban wildlife, these findings suggest that it should be possible to forecast the effects of urban land-use change on microbial diversity.
Databáze:	MEDLINE
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