Safety and value of skin test to sex hormones and sex hormone sensitivity desensitization in women with premenstrual syndrome.
| Autor: | Itsekson AM; Myofascial Pain Clinic, Rehabilitation Center, Sheba Medical Center, Israel., Yonit B; Eve Medical Systems Ltd., Israel., Ze'ev IH; Department of Neurology, Sheba Medical Center, Israel., Matitiyahu Z; Department of Gynecology and PMS Clinic, Sheba Medical Center, Israel., Shmuel K; Institute of Allergy and Clinical Immunology, Research Authority, Sourasky Medical Center, Israel. |
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| Jazyk: | angličtina |
| Zdroj: | The World Allergy Organization journal [World Allergy Organ J] 2019 Jun 08; Vol. 12 (6), pp. 100041. Date of Electronic Publication: 2019 Jun 08 (Print Publication: 2019). |
| DOI: | 10.1016/j.waojou.2019.100041 |
| Abstrakt: | Background: Hypersensitivity to one's own sex hormones is not a new concept but it is an underappreciated one. Such a phenomenon may explain a large proportion of symptoms related to the menstrual cycle (such as premenstrual syndrome, PMS), cyclic pain syndromes or unexplained infertility. In this study we propose a novel diagnostic tool of hormonal skin testing which reveals sex hormones sensitivity with high clinical correlation, and a subsequent successful desensitization technique. Methods: A group of 35 women with confirmed diagnosis of PMS were enrolled in the study in which they underwent a hormonal skin diagnostic skin testing procedure by intradermal injections of Progesterone (P), Estradiol (E2), Estrone (E1) and Estriol (E3). Skin reaction was monitored, and according to the reaction the patients were treated by serial desensitization by similar serial injections or placebo solvent. Response to treatment was monitored by assessing the change in the severity of PMS related symptoms. Results: We show a positive correlation between PMS severity and skin sensitivity to sex hormones. Subsequent desensitization procedure led to a significant improvement in the severity of PMS related symptoms. Conclusions: The testing and desensitization procedure is safe, sensitive and bares a high therapeutic potential in approach to resistant hormonal cycle related syndromes. Clinicaltrialsgov Identifier: NCT00873262: Evaluation of Safety/Efficacy of Diagnostic Skin Test Panel and Desensitization Hormone Kit for Treatment of Premenstrual Syndrome (PMS) 2009. |
| Databáze: | MEDLINE |
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