Analysis of Ki-67 Expression in Oral Premalignant Lesions and Normal Oral Mucosa: An Immunohistochemical Study.

Autor: Beevi BH; Department of Oral Pathology, Educare Institute of Dental Sciences, Malappuram, Kerala, India., Nayak SR; Department of Oral Pathology, Educare Institute of Dental Sciences, Malappuram, Kerala, India., Peter CD; Department of Oral Pathology, Educare Institute of Dental Sciences, Malappuram, Kerala, India., Haridas AK; Department of Oral Surgery, Educare Institute of Dental Sciences, Malappuram, Kerala, India., Jacob L; Department of Oral Surgery, Educare Institute of Dental Sciences, Malappuram, Kerala, India., Aboobakker A; Department of Oral Medicine and Radiology, Educare Institute of Dental Sciences, Malappuram, Kerala, India.
Jazyk: angličtina
Zdroj: Journal of pharmacy & bioallied sciences [J Pharm Bioallied Sci] 2019 May; Vol. 11 (Suppl 2), pp. S232-S235.
DOI: 10.4103/JPBS.JPBS_305_18
Abstrakt: Aim: This study aimed to evaluate the Ki-67 expression in oral premalignant lesions and normal oral mucosa.
Materials and Methods: The cases were selected on the basis of the details obtained from the patients. A total of 45 specimens were divided into three groups: Group 1 (normal mucosa), Group 2 (clinically and histologically diagnosed as oral lichen planus), and Group 3 (clinically and histologically diagnosed as leukoplakia). Specimens were prepared and the slides for Ki-67 were observed under light microscope with a magnification of ×400. The tissue samples were thoroughly examined, and the pattern of expression was analyzed semiquantitatively by counting the number of positive cells.
Results: The mean positive cell count of normal mucosa was 23.20 ± 2.89, of oral lichen planus was 42.82 ± 2.65, and of leukoplakia was 82.14 ± 3.10. There was a statistically significant difference of expression observed between the groups ( P < 0.001). On multiple comparisons using Tukey post hoc test, a statistical difference was found between all the three groups.
Conclusion: Ki-67 is an easily applicable marker of cell proliferation whose expression correlates well with the disease progression.
Competing Interests: There are no conflicts of interest.
Databáze: MEDLINE
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