Is polycystic kidney disease associated with malignancy in children?

Autor: Friend BD; Department of Pediatrics, UCLA Mattel Children's Hospital, Los Angeles, California.; Department of Pediatrics, UCSF Benioff Children's Hospital, San Francisco, California., Wolfe Schneider K; Section of Hematology, Oncology, and Bone Marrow Transplantation, University of Colorado Anschutz Medical Campus, Children's Hospital Colorado, Aurora, Colorado., Garrington T; Section of Hematology, Oncology, and Bone Marrow Transplantation, University of Colorado Anschutz Medical Campus, Children's Hospital Colorado, Aurora, Colorado., Truscott L; Department of Pediatrics, UCLA Mattel Children's Hospital, Los Angeles, California., Martinez-Agosto JA; Department of Pediatrics, UCLA Mattel Children's Hospital, Los Angeles, California.; Department of Human Genetics, UCLA David Geffen School of Medicine, Los Angeles, California.; UCLA Clinical Genomics Center, Los Angeles, California., Venick RS; Department of Pediatrics, UCLA Mattel Children's Hospital, Los Angeles, California., Tsai Chambers E; Department of Pediatrics, UCLA Mattel Children's Hospital, Los Angeles, California.; Division of Pediatric Nephrology, Department of Pediatrics, Duke University, Durham, North Carolina., Weng P; Department of Pediatrics, UCLA Mattel Children's Hospital, Los Angeles, California., Farmer DG; Department of Surgery, UCLA David Geffen School of Medicine, Los Angeles, California., Chang VY; Department of Pediatrics, UCLA Mattel Children's Hospital, Los Angeles, California.; UCLA's Jonsson Comprehensive Cancer Center, Los Angeles, California., Federman N; Department of Pediatrics, UCLA Mattel Children's Hospital, Los Angeles, California.; UCLA's Jonsson Comprehensive Cancer Center, Los Angeles, California.; Department of Orthopaedics, UCLA David Geffen School of Medicine, Los Angeles, California.
Jazyk: angličtina
Zdroj: Molecular genetics & genomic medicine [Mol Genet Genomic Med] 2019 Jul; Vol. 7 (7), pp. e00725. Date of Electronic Publication: 2019 Jun 14.
DOI: 10.1002/mgg3.725
Abstrakt: Background: Polycystic kidney disease (PKD) is an inherited condition characterized by progressive development of end-stage renal disease, hypertension, hepatic fibrosis, and cysts in the kidney, liver, pancreas, spleen, thyroid, and epididymis. While malignancies have been reported in association with PKD in adults, the incidence of malignancies in children with PKD is not currently known.
Methods: We report on five patients with a known history of PKD who developed a malignancy as children at the University of California, Los Angeles and the University of Colorado Anschutz Medical Campus. Patients were included from 2012 to 2017.
Results: We present five patients with a history of PKD diagnosed with a malignancy during childhood without any additional known mutations to suggest a genetic predisposition to develop cancer. This includes the first reported case of hepatocellular carcinoma in a patient with autosomal recessive polycystic kidney disease.
Conclusion: Our report illustrates the potential that PKD may be associated with an increased risk for developing cancer, even in children. Further research is necessary to better understand this relationship.
(© 2019 The Authors. Molecular Genetics & Genomic Medicine published by Wiley Periodicals, Inc.)
Databáze: MEDLINE
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