Association of some hemostasis and endothelial dysfunction factors with probability of presence of vulnerable atherosclerotic plaques in patients with coronary atherosclerosis.

Autor: Ragino YI; Research Institute of Internal and Preventive Medicine-Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, st.B.Bogatkova 175/1, Novosibirsk, 630089, Russia. ragino@mail.ru., Striukova EV; Research Institute of Internal and Preventive Medicine-Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, st.B.Bogatkova 175/1, Novosibirsk, 630089, Russia. stryukova.j@mail.rutel., Murashov IS; The Federal State Budgetary Institution 'National Medical Research Center named after Academician E.N. Meshalkin' of the Ministry of Health of the Russian Federation, Rechkunovskaya 15, Novosibirsk, 630055, Russia., Polonskaya YV; Research Institute of Internal and Preventive Medicine-Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, st.B.Bogatkova 175/1, Novosibirsk, 630089, Russia., Volkov AM; The Federal State Budgetary Institution 'National Medical Research Center named after Academician E.N. Meshalkin' of the Ministry of Health of the Russian Federation, Rechkunovskaya 15, Novosibirsk, 630055, Russia., Kurguzov AV; The Federal State Budgetary Institution 'National Medical Research Center named after Academician E.N. Meshalkin' of the Ministry of Health of the Russian Federation, Rechkunovskaya 15, Novosibirsk, 630055, Russia., Chernjavskii AM; The Federal State Budgetary Institution 'National Medical Research Center named after Academician E.N. Meshalkin' of the Ministry of Health of the Russian Federation, Rechkunovskaya 15, Novosibirsk, 630055, Russia., Kashtanova EV; Research Institute of Internal and Preventive Medicine-Branch of the Institute of Cytology and Genetics, Siberian Branch of Russian Academy of Sciences, st.B.Bogatkova 175/1, Novosibirsk, 630089, Russia.
Jazyk: angličtina
Zdroj: BMC research notes [BMC Res Notes] 2019 Jun 13; Vol. 12 (1), pp. 336. Date of Electronic Publication: 2019 Jun 13.
DOI: 10.1186/s13104-019-4360-7
Abstrakt: Objective: The study was dedicated to investigation of some hemostasis and endothelial dysfunction factors association with probability of presence of vulnerable atherosclerotic plaques in coronary arteries in men with atherosclerosis.
Results: The blood levels of factor VII, factor XII and MCP-1 were higher, and concentration of sVCAM-1 lower in men with vulnerable atherosclerotic plaques in the coronary arteries, compared to men who had stable plaques. Have been revealed correlation links between the blood levels of factor II, factor XII, MCP-1 and the presence of vulnerable atherosclerotic plaques in the coronary arteries. Results of logistic regression analysis showed that the relative risk of present of vulnerable atherosclerotic plaques in the coronary arteries is associated with an elevated blood level of factor XII and MCP-1.
Databáze: MEDLINE
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