Cortisol Correlates with Structural Magnetic Resonance Imaging Parameters in Middle Aged Bulgarian Patients with Metabolic Syndrome: A Pilot Study.

Autor:	Bahchevanov KM; Department of Neurology, Faculty of Medicine, Medical University of Plovdiv, Plovdiv, Bulgaria., Atanassova PA; Department of Neurology, Faculty of Medicine, Medical University of Plovdiv, Plovdiv, Bulgaria., Chompalov KA; Department of Neurology, Faculty of Medicine, Medical University of Plovdiv, Plovdiv, Bulgaria., Mitkov MD; Second Department of Internal Diseases, Section of Endocrinology, Faculty of Medicine, Medical University of Plovdiv, Plovdiv, Bulgaria., Milev BI; Russev Independent Medical Laboratory, Plovdiv, Bulgaria., Terzieva DD; Department of Clinical Laboratory, Faculty of Pharmacy, Medical University of Plovdiv, Plovdiv, Bulgaria., Naydenov VI; Department of Neurology, Faculty of Medicine, Medical University of Plovdiv, Plovdiv, Bulgaria., Dosheva VS; Department of Neurology, Faculty of Medicine, Medical University of Plovdiv, Plovdiv, Bulgaria., Masaldjieva RI; Department of Healthcare Management, Faculty of Public Health, Medical University of Plovdiv, Plovdiv, Bulgaria., Velkova KG; Department of Diagnostic Imaging, Faculty of Medicine, Medical University of Plovdiv, Plovdiv, Bulgaria., Sirakov NV; Department of Diagnostic Imaging, Faculty of Medicine, Medical University of Plovdiv, Plovdiv, Bulgaria., Kilova KP; Department of Medical Informatics, Biostatistics and E-learning, Faculty of Public Health, Medical University of Plovdiv, Plovdiv, Bulgaria.
Jazyk:	angličtina
Zdroj:	Folia medica [Folia Med (Plovdiv)] 2018 Dec 01; Vol. 60 (4), pp. 546-552.
DOI:	10.2478/folmed-2018-0029
Abstrakt:	Background: There is a dose-dependent relationship between chronically increased cortisol levels and the number of metabolic syndrome (MetS) components. Both cortisol and MetS are linked to various brain abnormalities. Aim: To investigate an association of MetS components and salivary cortisol levels with cortical thickness in middle-aged Bulgarian patients with MetS. Materials and Methods: We examined 26 healthy volunteers (mean age 50, 16±3.1 yrs) divided into two groups depending on whether or not they were diagnosed with MetS. Salivary cortisol was sampled and tested at two time points -morning and evening. Cortical thickness measures were obtained from structural T1-images using FreeSurfer software. We performed vertex-wise analysis across entire cortex and for preselected brain regions in frontal, temporal and cingulate cortex partial correlation analysis, accounting for gender. Results: The control group consisted of 12 women; in the MetS group there were 6 men and 8 women. The whole brain analysis showed that waist circumference (WC) was negatively correlated with cortical thickness in rostro-lateral area in left frontal lobe and the right lateral orbito-frontal cortex. Morning cortisol levels, accounting for sex and WC, correlated negatively with thickness in left superior temporal area (r = -0.477, p = 0.039) and entorhinal area (r = -0.465, p = 0.045) and left mediotemporal cortex (r = -0.477, p = 0.038). Conclusion: Our pilot study confirmed that WC is associated with brain atrophic changes mainly in the frontal lobe. Our finding that cortisol levels negatively correlate with thinning of the cortex in temporal lobe should be further explored in subsequent study.
Databáze:	MEDLINE
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