Dietary exposure to perfluoroalkyl acids, brominated flame retardants and health risk assessment in the French infant total diet study.

Autor: Rivière G; French Agency for Food, Environmental and Occupational Health & Safety, 14 rue Pierre & Marie Curie, F-94700, Maisons-Alfort, France. Electronic address: gilles.riviere@anses.fr., Jean J; French Agency for Food, Environmental and Occupational Health & Safety, 14 rue Pierre & Marie Curie, F-94700, Maisons-Alfort, France., Gorecki S; French Agency for Food, Environmental and Occupational Health & Safety, 14 rue Pierre & Marie Curie, F-94700, Maisons-Alfort, France., Hulin M; French Agency for Food, Environmental and Occupational Health & Safety, 14 rue Pierre & Marie Curie, F-94700, Maisons-Alfort, France., Kolf-Clauw M; French Agency for Food, Environmental and Occupational Health & Safety, 14 rue Pierre & Marie Curie, F-94700, Maisons-Alfort, France., Feidt C; French Agency for Food, Environmental and Occupational Health & Safety, 14 rue Pierre & Marie Curie, F-94700, Maisons-Alfort, France., Picard-Hagen N; French Agency for Food, Environmental and Occupational Health & Safety, 14 rue Pierre & Marie Curie, F-94700, Maisons-Alfort, France., Vasseur P; French Agency for Food, Environmental and Occupational Health & Safety, 14 rue Pierre & Marie Curie, F-94700, Maisons-Alfort, France., Le Bizec B; French Agency for Food, Environmental and Occupational Health & Safety, 14 rue Pierre & Marie Curie, F-94700, Maisons-Alfort, France., Sirot V; French Agency for Food, Environmental and Occupational Health & Safety, 14 rue Pierre & Marie Curie, F-94700, Maisons-Alfort, France.
Jazyk: angličtina
Zdroj: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association [Food Chem Toxicol] 2019 Sep; Vol. 131, pp. 110561. Date of Electronic Publication: 2019 Jun 08.
DOI: 10.1016/j.fct.2019.06.008
Abstrakt: Perfluoroalkyl acids (PFAAs) and brominated flame retardants (BFRs) are widely used and present in human food. Due to the increased susceptibility to pollutants of the young children, we conducted a total diet study focusing on this population. Around 200 baby and common food composite samples, prepared "as consumed", have been analysed for PFAAS, hexabromocyclododecanes, polybrominated biphenyls, polybrominated diphenyl ethers and tetrabromobisphenol A. The dietary exposure of 705 children aged 1-36 months was assessed. PFAAS were detected only in one fish sample. Detection rates varied from 4 to 93% for BFRs, depending on the congeners. Regarding the provisional health-based guidance values set by EFSA in 2018 for PFOA and PFOS at 0.8 and 1.8 ng kg bw -1 .d -1 , respectively, 20-100% of children exceeded them, depending on the age. Efforts should be made to decrease the PFAAs contamination of common foods. This study also highlighted that for other PFAAs, toxicological studies are needed to set dietary health-based guidance values, to assess their related health risk. Conversely, dietary exposures to BRFs were much lower than the respective health based guidance values or margins of safety were high enough, and consequently not considered at-risk due to very low contamination of the infant specific foods.
(Copyright © 2019 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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