| Autor: |
Moskalenko MI; Belgorod National Research University, Belgorod, Russia., Ponomarenko IV; Belgorod National Research University, Belgorod, Russia., Polonikov AV; Kursk State Medical University, Kursk, Russia., Zhernakova NI; Belgorod National Research University, Belgorod, Russia., Efremova OA; Belgorod National Research University, Belgorod, Russia., Churnosov MI; Belgorod National Research University, Belgorod, Russia. |
| Jazyk: |
ruština |
| Zdroj: |
Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova [Zh Nevrol Psikhiatr Im S S Korsakova] 2019; Vol. 119 (3. Vyp. 2), pp. 11-17. |
| DOI: |
10.17116/jnevro201911903211 |
| Abstrakt: |
To study the interaction of polymorphic markers of matrix metalloproteinases (MMP) and chronic stress in the development of stroke associated with hypertension. MATERIAL AND METHODS: A total of 830 patients, including 303 patients with ischemic stroke associated with essential hypertension (EH) and 527 patients with EH without stroke, were examined. The study of metalloproteinases SNP was carried out using real-time PCR. The functional significance and influence of polymorphic loci on gene expression was studied using of HaploReg (v4.1) (http://archive.broadinstitute.org) and GTEx-portal (http://www.gtexportal.org). RESULTS AND CONCLUSION: An association of the genotype GG (rs11568818) of MMP7 with a high risk of stroke in patients exposed to regular stress (OR=1.71) was observed. It was found that allele 5A and genotype 5A/5A (rs3025058) of MMP3 had a protective effect on the development of stroke in patients without regular stress in the anamnesis (OR=0.73 and OR=0.60, respectively). Those SNPs are localized in the region of histone proteins H3K4me1 and H3K4me3, in the region of hypersensitivity to DNase-1, in the region of binding of regulatory proteins and transcription factors. The polymorphic locus rs11568818 is associated with the expression level of MMP7. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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