DBDS Genomic Cohort, a prospective and comprehensive resource for integrative and temporal analysis of genetic, environmental and lifestyle factors affecting health of blood donors.

Autor:	Hansen TF; Danish Headache Center, Rigshospitalet Glostrup, Glostrup, Denmark.; Center for Protein Research, Kobenhavns Universitet Sundhedsvidenskabelige Fakultet, Kobenhavn, Denmark., Banasik K; Center for Protein Research, Kobenhavns Universitet Sundhedsvidenskabelige Fakultet, Kobenhavn, Denmark., Erikstrup C; Immunology, Aarhus Universitetshospital, Aarhus, Denmark., Pedersen OB; Department of Immunology, Neastved Hospital, Neastved, Denmark., Westergaard D; Center for Protein Research, Kobenhavns Universitet Sundhedsvidenskabelige Fakultet, Kobenhavn, Denmark., Chmura PJ; Center for Protein Research, Kobenhavns Universitet Sundhedsvidenskabelige Fakultet, Kobenhavn, Denmark., Nielsen K; Immunology, Aalborg University Hospital, Aalborg, Denmark., Thørner L; Immunology, Rigshospitalet, Kobenhavn, Denmark., Hjalgrim H; Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark., Paarup H; Immunology, Odense Universitetshospital, Odense, Denmark., Larsen MAH; Immunology, Rigshospitalet, Kobenhavn, Denmark., Petersen M; Immunology, Aarhus Universitetshospital, Aarhus, Denmark., Jennum P; Danish Center for Sleep Medicine, Department of Clinical Neurophysiology, Glostrup Hospital, Copenhagen, Denmark.; Center for Healthy Ageing, University of Copenhagen, Copenhagen, Denmark., Andersen S; Economics, Copenhagen Business School, Frederiksberg, Denmark., Nyegaard M; Biomedicine, Aarhus Universitet Health, Aarhus, Denmark., Jemec GBE; Dermatology, Roskilde University Hospital, Roskilde, Denmark., Olesen J; Danish Headache Center, Rigshospitalet Glostrup, Glostrup, Denmark., Werge T; Clinical Medicine, Kobenhavns Universitet Sundhedsvidenskabelige Fakultet, Kobenhavn, Denmark.; Institute of Biological Psychiatry, Mental Health Centre Sct. Hans, Copenhagen University Hospital, Roskilde, Denmark., Johansson PI; Department of Clinical Immunology, Copenhagen University Hospital, Copenhagen, Denmark., Sørensen E; Immunology, Rigshospitalet, Kobenhavn, Denmark., Brunak S; Center for Protein Research, Kobenhavns Universitet Sundhedsvidenskabelige Fakultet, Kobenhavn, Denmark., Ullum H; Immunology, Rigshospitalet, Kobenhavn, Denmark., Burgdorf KS; Immunology, Rigshospitalet, Kobenhavn, Denmark.
Jazyk:	angličtina
Zdroj:	BMJ open [BMJ Open] 2019 Jun 09; Vol. 9 (6), pp. e028401. Date of Electronic Publication: 2019 Jun 09.
DOI:	10.1136/bmjopen-2018-028401
Abstrakt:	Purpose: To establish a cohort that enables identification of genomic factors that influence human health and empower increased blood donor health and safe blood transfusions. Human health is complex and involves several factors, a major one being the genomic aspect. The genomic era has resulted in many consortia encompassing large samples sizes, which has proven successful for identifying genetic factors associated with specific traits. However, it remains a big challenge to establish large cohorts that facilitate studies of the interaction between genetic factors, environmental and life-style factors as these change over the course of life. A major obstacle to such endeavours is that it is difficult to revisit participants to retrieve additional information and obtain longitudinal, consecutive measurements. Participants: Blood donors (n=110 000) have given consent to participate in the Danish Blood Donor Study. The study uses the infrastructure of the Danish blood banks. Findings to Date: The cohort comprises extensive phenotype data and whole genome genotyping data. Further, it is possible to retrieve additional phenotype data from national registries as well as from the donors at future visits, including consecutive measurements. Future Plans: To provide new knowledge on factors influencing our health and thus provide a platform for studying the influence of genomic factors on human health, in particular the interaction between environmental and genetic factors. Competing Interests: Competing interests: None declared. (© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)
Databáze:	MEDLINE
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