| Autor: |
Botteri FM; Gene Expression Laboratory, Salk Institute, San Diego, California 92138., van der Putten H, Wong DF, Sauvage CA, Evans RM |
| Jazyk: |
angličtina |
| Zdroj: |
Molecular and cellular biology [Mol Cell Biol] 1987 Sep; Vol. 7 (9), pp. 3178-84. |
| DOI: |
10.1128/mcb.7.9.3178-3184.1987 |
| Abstrakt: |
The hypothalamic peptide growth hormone-releasing factor (GRF) regulates the secretion and production of growth hormone from the anterior pituitary (M. C. Gelato and G. R. Merriam, Annu. Rev. Physiol. 48:569-591). To study GRF gene regulation, transgenic mice were generated that harbor the human GRF promoter fused to the coding sequences from the simian virus 40 early region. These mice had normal hypothalamic functions but unexpectedly suffered from severe thymic hyperplasia. Immunohistochemical analysis revealed that large T antigen was expressed in the thymic epithelial cells. These cells have endocrine properties and are known to produce thymic hormones [corrected]. The thymic hyperplasia was the apparent consequence of inappropriate production of T-cell maturation factors by epithelial cells and could involve increased self renewal of apparently normal T stem cells in the thymus. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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