| Autor: |
Jiang H; School of Electrical and Computer Engineering, Purdue University, West Lafayette, IN 47907, USA. bziaie@purdue.edu., Ochoa M, Waimin JF, Rahimi R, Ziaie B |
| Jazyk: |
angličtina |
| Zdroj: |
Lab on a chip [Lab Chip] 2019 Jun 25; Vol. 19 (13), pp. 2265-2274. |
| DOI: |
10.1039/c9lc00206e |
| Abstrakt: |
This work presents a low-cost, passive, flexible, polymeric pump for topical drug delivery which uses wound pH as a trigger for localized drug release. Its operation relies on a pH-responsive hydrogel actuator which swells when exposed to the alkaline pH of an infected wound. The pump enables slow release (<0.1 μL min-1) of aqueous anti-bacterial solution for up to 4 hours and sustains against up to 8 kPa of backpressure. Featuring a scalable layer-by-layer fabrication technique to expand the pump into a 2 × 2 array, the device can dispense 50 μl onto a 160 mm2 dermal coverage within 4 hours. Robustness tests show that when integrated within a medical adhesive, the device can be worn around the forearm and can withstand various daily activities (non-intensive) for up to 12 hours. In vitro experiments demonstrate a 58 times decrease of live P. aeruginosa after 24 hours of the pump assisted antibiotics treatment. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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