Increased Skin Conductance Response in the Immediate Aftermath of Trauma Predicts PTSD Risk.

Autor:	Hinrichs R; Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia., van Rooij SJ; Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia., Michopoulos V; Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia.; Yerkes National Primate Research Center, Atlanta, Georgia., Schultebraucks K; Department of Psychiatry, New York University School of Medicine, New York, New York., Winters S; Department of Psychiatry and Behavioral Neurosciences, Wayne State University, Detroit, MI., Maples-Keller J; Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia., Rothbaum AO; Case Western Reserve University, Cleveland, Ohio., Stevens JS; Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia., Galatzer-Levy I; Department of Psychiatry, New York University School of Medicine, New York, New York., Rothbaum BO; Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia., Ressler KJ; Harvard/McLean Hospital, Boston, Massachusetts.; Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia., Jovanovic T; Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia.; Department of Psychiatry and Behavioral Neurosciences, Wayne State University, Detroit, MI.
Jazyk:	angličtina
Zdroj:	Chronic stress (Thousand Oaks, Calif.) [Chronic Stress (Thousand Oaks)] 2019 Jan-Dec; Vol. 3. Date of Electronic Publication: 2019 Apr 24.
DOI:	10.1177/2470547019844441
Abstrakt:	Background: Exposure to a traumatic event leads to posttraumatic stress disorder (PTSD) in 10-20% of exposed individuals. Predictors of risk are needed to target early interventions to those who are most vulnerable. The objective of the study was to test whether a noninvasive mobile device that measures a physiological biomarker of autonomic nervous system activation could predict future PTSD symptoms. Methods: Skin conductance response (SCR) was collected during a trauma interview in the emergency department within hours of exposure to trauma in 95 individuals. Trajectories of PTSD symptoms over 12 months post-trauma were identified using Latent Growth Mixture Modeling. Results: SCR was significantly correlated with the probability of being in the chronic PTSD trajectory following trauma exposure in the ED (r=0.489, p<0.000001). Lasso regression with elastic net was performed with demographic and clinical measures obtained in the ED, demonstrating that SCR was the most significant predictor of the chronic PTSD trajectory ( p <0.00001). Conclusions: The current study is the first prospective study of PTSD showing SCR in the immediate aftermath of trauma predicts subsequent development of chronic PTSD. This finding points to an easily obtained, and neurobiologically informative, biomarker in emergency departments that can be disseminated to predict the development of PTSD. Competing Interests: Declaration of Conflicting Interests No authors report any conflicting interests.
Databáze:	MEDLINE
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